摘要
目的:探讨替诺福韦酯抗病毒治疗对慢性乙型肝炎患者免疫炎性反应及临床疗效的影响。方法:选择2018年6月~2020年7月收治的慢性乙型肝炎患者85例为研究对象,根据治疗方法分为实验组44例和对照组41例,对照组给予恩替卡韦分散片口服治疗,实验组给予替诺福韦酯口服治疗。治疗12个月,比较两组临床疗效、血清炎性因子、T淋巴细胞亚群、不良反应。结果:实验组慢性乙型肝炎患者丙氨酸氨基转移酶(ALT)复常率、乙型肝炎e抗原(HbeAg)转阴率、乙肝病毒脱氧核糖核酸(HBV DNA)转阴率明显高于对照组(P<0.05);血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)明显低于对照组,白细胞介素-10(IL-10)明显高于对照组(P<0.05);T淋巴细胞CD3+、CD4+、CD4+/CD8+明显高于对照组(P<0.05);两组恶心等不良反应比较无统计学意义(P>0.05)。结论:替诺福韦酯抗病毒治疗有助于提高慢性乙型肝炎临床疗效,可能与拮抗炎症反应、调节细胞免疫功能等因素有关。
Objective:To study the effect of tenofovir antiviral therapy on immunoinflammatory response and clinical efficacy in patients with chronic hepatitis B.Methods:85 cases patients with CHB from June 2018 to July 2020 were selected and divided into experimental group(44 cases)and control group(41 cases).The control group was given entecavir dispersible tablets orally therapy,the experimental group was given tenofovir disoprox orally therapy.12 months after treatment,the clinical efficacy,serum inflammatory factors,T lymphocyte subsets and adverse reactions were compared between the two groups.Results:The recovery rate of ALT,HbeAg negative conversion rate,and the HBV-DNA negative conversion rate in the experimental group were significantly higher than those in the control group(P<0.05).Serum TNF-αand IL-6 in the experimental group were significantly lower than those in the control group,and the IL-10 was significantly higher than that in the control group(P<0.05).T lymphocytes CD3+,CD4+,CD4+/CD8+in the experimental group were significantly higher than those in the control group(P<0.05).There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Tenofovir disoprox antiviral therapy helps to improve the clinical efficacy,which may be related to antagonism of inflammatory response and regulation cellular immune function.
作者
方坚
张佳祥
Fang Jian;Zhang Jiaxiang(The No.3 People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350108;Department ofInfection,The 909th Hospital of the Joint Logistics Service Support Force,Zhangzhou 363000)
出处
《数理医药学杂志》
CAS
2021年第11期1634-1636,共3页
Journal of Mathematical Medicine
基金
福建省社会发展科技引导性项目(2016Y0068)。
关键词
慢性乙型肝炎
替诺福韦酯
炎性因子
T淋巴细胞
chronic hepatitis B
tenofovir disoprox
inflammatory factors
T lymphocyte
