摘要
目的探讨不同剂量阿托伐他汀治疗经皮冠状动脉介入治疗(PCI)围术期老年急性冠状动脉综合征(ACS)的临床疗效。方法74例老年ACS患者,根据随机抽签法分成对照组(34例)及观察组(40例)。对照组患者给予阿托伐他汀20 mg/d,但术前2 h避免用药;观察组患者给予阿托伐他汀80 mg/d,且术前2 h给予20 mg阿托伐他汀。比较两组血管内皮功能、炎症指标、心血管事件与造影剂肾病发生率。结果治疗后,两组超敏C反应蛋白(hs-CRP)、内皮素-1(ET-1)水平较本组治疗前降低,一氧化氮(NO)水平较本组治疗前升高,且观察组hs-CRP、ET-1水平低于对照组,NO水平高于对照组,差异均有统计学意义(P<0.05)。观察组心血管事件发生率7.5%低于对照组的26.5%,差异有统计学意义(χ^(2)=4.868,P=0.027<0.05)。观察组造影剂肾病发生率为2.5%(1/40),低于对照组的17.6%(6/34),差异有统计学意义(χ^(2)=4.923,P=0.026<0.05)。结论大剂量阿托伐他汀治疗老年ACS效果优良,值得推广。
Objective To discuss the clinical efficacy of atorvastatin on elderly patients with acute coronary syndrome(ACS)during perioperative period of percutaneous coronary intervention(PCI).Methods A total of 74 elderly patients with ACS were divided into control group(34 cases)and observation group(40 cases)according to random lottery method.Patients in the control group were treated with atorvastatin 20 mg/d,but the medication was avoided 2 h before operation,and patients in the observation group were treated with atorvastatin 80 mg/d,and 20 mg atorvastatin 2 h before operation.The vascular endothelial function,inflammation index,and incidence of cardiovascular events and contrast-induced nephropathy were compared between the two groups.Results After treatment,the levels of high-sensitivity C-reactive protein(hs-CRP)and endothelin-1(ET-1)in the two groups were lower than those before treatment,and the levels of nitric oxide(NO)were higher than those before treatment;the levels of hs-CRP and ET-1 in the observation group were lower than those in the control group,and the levels of NO were higher than those in the control group;all the differences were statistically significant(P<0.05).The incidence of cardiovascular events 7.5%in the observation group was lower than 26.5%in the control group,and the difference was statistically significant(χ^(2)=4.868,P=0.027<0.05).The incidence of contrast-induced nephropathy in the observation group was 2.5%(1/40),which was lower than 17.6%(6/34)in the control group,and the difference was statistically significant(χ^(2)=4.923,P=0.026<0.05).Conclusion High-dose atorvastatin has excellent effects in the treatment of elderly ACS,and is worthy of promotion.
作者
李巧艳
LI Qiao-yan(Second Department of Cardiology,Xingcheng People’s Hospital,Xingcheng 125100,China)
出处
《中国实用医药》
2021年第29期112-114,共3页
China Practical Medicine
