摘要
目的探究对2型糖尿病患者应用长效胰岛素联合口服降糖药治疗的临床疗效及治疗安全性。方法142例2型糖尿病患者,以随机双盲方式分为实验组及对照组,每组71例。实验组采用长效胰岛素联合口服降糖药治疗,对照组单纯口服降糖药治疗。比较两组患者的血糖指标水平,不良反应发生情况,临床疗效。结果实验组的糖化血红蛋白(5.49±0.45)%、空腹血糖(6.31±0.52)mmol/L、餐后2 h血糖(8.14±0.98)mmol/L均显著低于对照组的(9.25±1.27)%、(11.37±1.69)mmol/L、(15.78±2.49)mmol/L,差异具有统计学意义(P<0.05)。实验组患者的不良反应发生率4.23%显著低于对照组的18.31%,差异具有统计学意义(P<0.05)。实验组患者的总有效率98.59%显著高于对照组85.92%,差异具有统计学意义(P<0.05)。结论对2型糖尿病患者应用长效胰岛素联合口服降糖药治疗,可稳定患者的血糖水平,提升用药安全性,改善患者临床症状,优化临床疗效。
Objective To investigate the clinical efficacy and safety of long-acting insulin combined with oral hypoglycemic drugs in the treatment of type 2 diabetes mellitus.Methods A total of 142 patients with type 2 diabetes mellitus were randomly divided into the experimental group and the control group according to random double-blind method,with 71 cases in each group.The experimental group was treated with long-acting insulin and oral hypoglycemic drugs,and the control group was treated with oral hypoglycemic drugs alone.The blood glucose index levels,occurrence of adverse reactions,and clinical efficacy were compared between the two groups.Results The glycosylated hemoglobin(5.49±0.45)%,fasting blood glucose(6.31±0.52)mmol/L,and 2-h postprandial glucose(8.14±0.98)mmol/L in the experimental group were significantly lower than(9.25±1.27)%,(11.37±1.69)mmol/L,and(15.78±2.49)mmol/L in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions was 4.23%in the experimental group,which was significantly lower than 18.31%in the control group,and the difference was statistically significant(P<0.05).The total effective rate was 98.59%in the experimental group,which was significantly higher than 85.92%of the control group,and the difference was statistically significant(P<0.05).Conclusion The application of long-acting insulin combined with oral hypoglycemic drugs in patients with type 2 diabetes mellitus can stabilize the blood glucose level of patients,improve the safety of medication,improve the clinical symptoms of patients,and optimize the clinical efficacy.
作者
房思思
FANG Si-si(Fuxin Central Hospital,Fuxin 123000,China)
出处
《中国实用医药》
2021年第27期114-116,共3页
China Practical Medicine
关键词
2型糖尿病
长效胰岛素
降糖药
临床疗效
治疗安全性
Type 2 diabetes mellitus
Long-acting insulin
Hypoglycemic drugs
Clinical efficacy
Treatment safety
