摘要
CCL20、CCR6是由多种细胞产生的趋化因子,CCL20与CCR6结合后激发一系列的下游途径,参与各种恶性肿瘤的发生、发展,在乳腺癌的侵袭转移及化疗耐药过程也起到了重要的作用。上皮-间质转化(EMT)使细胞的黏附能力丧失,E-钙黏蛋白表达下调,间叶标志物和纤维链接蛋白表达上调,细胞运动能力和侵袭能力增强,也是肿瘤细胞转移过程中的一个关键步骤。本文就CCL20-CCR6生物轴及EMT对乳腺癌细胞的侵袭及转移的研究作一综述。
CCL20 and CCR6 are chemokines produced by a variety of cells.CCL20 and CCR6 combine to stimulate a series of downstream pathways,participate in the occurrence and development of various malignant tumors,and also play an important role in the invasion and metastasis of breast cancer and the process of chemotherapy resistance.Epithelial-mesenchymal transformation(EMT)is a key step in the process of tumor cell metastasis,which is characterized by loss of cell adhesion,down-regulation of E-cherherin expression,up-regulation of mesenchymal markers and fibrinectin expression,and enhancement of cell motor ability and invasion ability.This article reviews the research of CCL20-CCR6 biological axis and EMT on invasion and metastasis of breast cancer cells.
作者
袁思敏
杨勇
王雪莹
蔡凤林
章佳新
Yuan Simin;Yang Yong;Wang Xueying;Cai Fenglin;Zhang Jiaxin(Dalian Medical University,Dalian 116044,China;Sinopharm Dongfeng General Hospital,Shiyan 442008,China;Department of Thoracic and Breast Surgery,Subei People′s Hospital,Yangzhou 225001,China)
出处
《国际外科学杂志》
2021年第6期401-405,共5页
International Journal of Surgery
基金
国家自然科学基金(82072909)
苏北人民医院普通外科医学重点学科开放课题(ptwk202004)。
