摘要
眼底疾病种类繁多、病因复杂,既可以由代谢因素引起,也可以是炎症因素所致。荧光素眼底血管造影、光相干断层扫描等眼底影像学检查是诊断眼底疾病的主要方式,当其在判断病因和早期诊断时若能合理结合眼内液检测技术,优势会更大。眼内液是眼球内液体的总称,包括房水、玻璃体液等,其可以检验的分子成分包括DNA、RNA、抗原、抗体、细胞因子。随着分子检测技术和设备的进步,眼内液检测作为循证手段逐步被更多的眼底病专家共识和指南纳入,主要应用于感染性眼底疾病和伪装综合症的诊疗。合理地使用眼内液检测,有助于提升眼底疾病的个性化诊治效果,并减少不必要的药物过度使用。但值得注意的是,眼内液检测只是诸多工具中的一种,不能取代其他检查和临床经验。过度的眼内液检测,不仅因为有创增加了临床感染的风险,同时也会加重患者的负担。
There are many types of fundus diseases and their causes are complex.They can be caused by metabolic factors or inflammatory factors.Fundus examination and imaging examination tools are the main methods for diagnosing fundus diseases.However,in terms of determining the cause and early diagnosis,if the intraocular fluid detection technology can be reasonably combined,the advantages will be greater.Intraocular fluid is the general term for fluid in the eyeball,including aqueous humor,vitreous humor,etc.The molecular components that can be tested include DNA,RNA,antigens,antibodies,and cytokines.With the advancement of molecular testing technology and equipment,intraocular fluid testing as an evidence-based method has gradually been incorporated into the consensus and guidelines of more fundus disease experts,and is mainly used for infectious fundus diseases and camouflage syndromes.Reasonable use of intraocular fluid testing can help improve the personalized diagnosis and treatment of fundus diseases and reduce unnecessary drug overuse.However,it is worth noting that intraocular fluid detection is only one of many tools and cannot replace other examinations and clinical experience.Excessive intraocular fluid testing not only increases the risk of clinical infections because of invasiveness,but also increases the burden on patients.
作者
陶勇
石燕红
Tao Yong;Shi Yanhong
出处
《中华眼底病杂志》
CAS
CSCD
北大核心
2021年第7期497-502,共6页
Chinese Journal of Ocular Fundus Diseases
基金
国家自然科学基金(面上基金)(82070948)
北京市百千万人才工程(2020027)
顺义区"北京市科技成果转化统筹协调与服务平台"建设基金(SYGX202010)
北京市教育委员会科研计划项目(KM202010025020)。
关键词
眼房水
视网膜疾病
细胞因子类
述评
眼内液检测
Aqueous humor
Retinal diseases
Cytokines
Editorial
Examination of intraocular fluid
