摘要
杜松烷型倍半萜是一类双环倍半萜,立体化学复杂,具有广泛药理活性,如抗菌、抗炎、降糖等。迄今为止,已从多种植物和微生物中分离鉴定出具有不同结构及生物活性的杜松烷型化合物,相关杜松烷型倍半萜合酶的研究也取得较大进展。本文按5种结构类型对近4年(2017-2020年)文献发表的结构新颖的124个杜松烷型化合物进行整理,并对其药理活性进行归纳总结,同时介绍了代表性杜松烷型化合物生物合成途径的解析概况,归纳了该类天然产物生物合成过程中关键杜松烷型倍半萜合酶的研究进展,并讨论了该类天然产物的研究前景和目前面临的一些问题。
Cadinanes are a class of bicyclic sesquiterpenes with complex stereochemistry and broad pharmacological activities,such as antibacterial,anti-inflammatory,and hypoglycemic activities.To date,structurally diverse and bioactive cadinane sesquiterpenes have been isolated and identified from a variety of plants and microorganisms.Moreover,deeper understandings on cadinane sesquiterpene synthases have been made.This article categorized the 124 new cadinanes which were published in the literatures in the past four years(2017–2020)into five structural types,and presented their pharmacological activities.We also illustrated the elucidation of the biosynthetic pathways for typical cadinanes,summarized the research progress on cadinane sesquiterpene synthases.Finally,current challenges and future prospects were proposed and discussed.
作者
姜龙瑜
温艳华
彭雨
陈天娇
陈晶晶
杨金玲
巩婷
朱平
Longyu Jiang;Yanhua Wen;Yu Peng;Tianjiao Chen;Jingjing Chen;Jinling Yang;Ting Gong;Ping Zhu(State Key Laboratory of Bioactive Substance and Function of Natural Medicines&Key Laboratory of Biosynthesis of Natural Products of the National Health Commission,Institute of Materia Medica,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100050,China)
出处
《生物工程学报》
CAS
CSCD
北大核心
2021年第6期1952-1967,共16页
Chinese Journal of Biotechnology
基金
重大新药创制科技重大专项平台建设(No.2018ZX09711001-008-001)
中国医学科学院医学与健康科技创新工程协同创新项目(No.CIFMS-2017-I2M-4-004)
清华211-合成生物学学科建设(No.201920100801)资助。
关键词
杜松烷型倍半萜
结构类型
药理活性
生物合成
倍半萜合酶
cadinane sesquiterpenes
structure type
pharmacological activities
biosynthesis
sesquiterpene synthase
