摘要
为了了解郑州地区犬角膜溃疡的流行情况及感染病原菌对临床常用药物的敏感性,试验在2017年6月份—2019年12月份间跟踪调查了郑州市三家宠物医院全部眼科门诊病例共684例,选出犬眼科病例379例,其中犬角膜溃疡102例,对发病病因、发病率、发病品种、性别、年龄及治疗方法和治疗效果进行统计分析。同时以收治的102例犬角膜溃疡病例为研究对象,取样进行细菌分离培养和鉴定,对分离得到的菌株数最多的分离菌进行眼科常用药物的敏感性试验。结果表明:在102例角膜溃疡犬中,发病率较高的品种为贵宾、比熊、混血、柯基、京巴犬;年龄从2月龄至19岁不等,平均年龄为(5.80±0.54)岁;发病原因主要以外伤(22例,21.57%)和干眼症(14例,13.73%)为主;对角膜溃疡的治疗主要是药物治疗和手术治疗相结合的方法,以提高治疗有效率。在102份犬角膜溃疡样品中,99份样品细菌培养结果为阳性,以伪中间葡萄球菌感染为主。体外抑菌有效的抗生素有利福平、妥布霉素、头孢甲肟、环丙沙星和左氧氟沙星,敏感率分别为98.98%、97.96%、96.94%、96.94%、93.88%;而对红霉素、四环素和氯霉素耐药性较强,耐药率分别为96.94%、91.84%、51.02%。说明郑州地区犬角膜溃疡病因复杂,危害严重,应及早诊断,消除病因,选取合理的治疗方案,并针对不同的病原体选用相应的敏感药物进行治疗。
In order to understand the prevalence of canine corneal ulcers in Zhengzhou area and the sensitivity of infectious pathogens to commonly used clinical drugs,a total of 684 outpatients of all ophthalmology clinics in three pet hospitals in Zhengzhou City from June 2017 to December 2019 were followed up,and 379 canine ophthalmic cases were selected.Among them,there were 102 cases of canine corneal ulcers and the etiology,incidence,breed,gender,age,treatment methods and treatment effects of the disease were statistically analyzed.At the same time,102 cases of canine corneal ulcers were taken as the research object,samples were taken for bacterial culture and identification,and the isolates with the largest number of isolates were tested for the sensitivity of commonly used ophthalmic drugs.The results showed that among 102 cases of canine corneal ulcers,the breeds with a higher incidence were poodle,bichon,mixed-breed,corgi,and pekingese dogs;the age ranged from 2 months to 19 years,with an average age of(5.80±0.54)years old.The main causes of the disease were trauma(22 cases,21.57%)and dry eye(14 cases,13.73%).The treatment of corneal ulcers mainly adopted the method of combination of drug treatment and surgical treatment,in order to improve the treatment efficiency.Among 102 canine corneal ulcers samples,99 samples showed positive bacterial culture results,with mainly infections of Staphylococcus pseudintermedius.Antibacterially effective antibiotics in vitro were cefometoxime,rifampicin,tobramycin,levofloxacin and ciprofloxacin,and the sensitivity rates were 98.98%,97.96%,96.94%,96.94%,93.88%,respectively;while highly resistant to tetracycline,erythromycin and chloramphenicol,with resistance rates of 96.94%,91.84% and 51.02%,respectively.The results suggested that the cause of corneal ulcers in Zhengzhou area canines was complex and the harm was serious.Early diagnosis should be made to eliminate the cause;a reasonable treatment plan was chosen,and corresponding sensitive drugs for different pathogens for treatment were selected.
作者
张红超
王志浩
李建基
王亨
崔璐莹
ZHANG Hongchao;WANG Zhihao;LI Jianji;WANG Heng;CUI Luying(College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,China;Henan Vocational College of Agriculture,Zhengzhou 451450,China)
出处
《黑龙江畜牧兽医》
CAS
北大核心
2021年第10期80-84,共5页
Heilongjiang Animal Science And veterinary Medicine
关键词
犬
角膜溃疡
流行病学
耐药分析
中间葡萄球菌
canine
corneal ulcers
epidemiology
analysis of drug resistance
Staphylococcus pseudintermedius
