摘要
目的探究抗精神病治疗用于老年2型糖尿病(T2DM)伴精神障碍患者中的作用。方法随机选择2017年5月—2020年5月该院收治的100例老年T2DM并精神障碍患者为研究对象,采用随机数表法分成对照组和试验组,各50例。对照组予常规治疗,试验组在对照组基础上予富马酸喹硫平治疗。对比两组治疗前后血糖指标、简明精神病量表(BPRS)评分。结果治疗后试验组FPG(5.16±1.19)mmol/L、餐后2 h血糖(2 hPG)(7.43±2.51)mmol/L、糖化血红蛋白(HbA1c)(5.60±0.93)%低于对照组(5.95±1.29)mmol/L、(9.15±2.97)mmol/L、(7.03±1.16)%,差异有统计学意义(t=3.183、3.128、6.801,P<0.05);试验组治疗后BPRS评分(35.25±3.55)分低于对照组(41.30±4.15)分,差异有统计学意义(t=7.833,P<0.05)。结论老年T2DM伴精神障碍患者使用富马酸喹硫平治疗效果确切,能有效降低血糖水平,改善精神障碍症状,临床推广价值高。
Objective To explore the role of antipsychotic therapy in elderly patients with type 2 diabetes(T2DM)with mental disorders.Methods Randomly selected 100 elderly patients with T2DM and mental disorders admitted to the hospital from May 2017 to May 2020 as the research objects,and divided them into a control group and a test group with 50 cases each using a random number method.The control group received conventional treatment,and the test group was treated with quetiapine fumarate on the basis of the control group.The blood glucose index and the brief psychiatric scale(BPRS)scores before and after treatment were compared between the two groups.Results After treatment,FPG(5.16±1.19)mmol/L,2 hPG(7.43±2.51)mmol/L,HbA1c(5.60±0.93)%in the test group were lower than those in the control group(5.95±1.29)mmol/L,(9.15±2.97)mmol/L,(7.03±1.16)%,the difference was statistically significant(t=3.183,3.128,6.801,P<0.05);after treatment,the BPRS score(35.25±3.55)points of the test group was lower than that of the control group(41.30±4.15)points,the difference was statistically significant(t=7.833,P<0.05).Conclusion Quetiapine fumarate in elderly patients with T2DM and mental disorders has a definite therapeutic effect,which can effectively reduce blood sugar levels and improve symptoms of mental disorders,and has high clinical promotion value.
作者
张莹
ZHANG Ying(Department of Psychiatry,Tai'an Special Care Hospital,Tai'an,Shandong Province,271000 China)
出处
《中外医疗》
2021年第12期101-103,共3页
China & Foreign Medical Treatment
关键词
抗精神病治疗
2型糖尿病
炎症因子水平
老年
精神障碍
Antipsychotic treatment
Type 2 diabetes
Levels of inflammatory factors
Old age
Mental disorders
