首发精神分裂症患者抗精神病药物治疗对血脂代谢水平的影响研究被引量：21

Effect of Antipsychotics on Blood Lipid Metabolism in Patients with First-Episode Schizophrenia

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摘要目的探讨抗精神病药对首发精神分裂症住院患者血脂代谢的影响。方法对2014年6月1日～2015年5月31日期间符合美国《精神障碍诊断统计手册》第四版(DSM-Ⅳ)精神分裂症的诊断,并根据DSM-IV-TR轴Ⅰ障碍用临床定式检查(SCID-Ⅰ/P)进行评定、复核确诊的137例首发精神分裂症住院患者进行观察,根据服用的不同抗精神病药物(FGA组、SGA组和联合用药)进行分组,并随访1年后测定其总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇和三酰甘油等血脂情况。结果随访1年后,首发精神分裂症住院患者服用SGA组和联合用药(FGA+SGA)组总胆固醇水平分别为4.69±0.64 mmol/L和4.53±0.78 mmol/L,均高于FGA组4.32±0.73 mmol/L,且差异有统计学意义(F=3.435,P<0.05);SGA组和联合用药(FGA+SGA)组低密度脂蛋白胆固醇水平分别为2.51±0.39 mmol/L和2.42±0.46 mmol/L,亦高于FGA组2.35±0.61 mmol/L,且差异有统计学意义(F=3.231,P<0.05)。结论首发精神分裂症住院患者单用第二代抗精神病药物治疗及联合用药治疗均比单用第一代抗精神病药物更容易引发脂代谢异常。 Objective To explore the effect of antipsychotics on the blood lipid metabolism in the first-episode schizophrenia.Methods The patients with first-episode schizophrenia from June 1,2014to May 31,2015were met with the diagnosis of schizophrenia in the fourth edition(DSM-Ⅳ)of American Handbook of Diagnostic Statistics for Mental Disorder,and assessed them according to SCID-Ⅰ/P.The patients were divided into groups according to different antipsychotic drugs and followed up for 1year to collect the blood lipids including total cholesterol(TC),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C)and triglyceride(TG).Results The total cholesterol levels in SGA group and FGA+SGA group were 4.69±0.64mmol/L and 4.53±0.78mmol/L,respectively,which were higher than those in FGA group 4.32±0.73mmol/L.The difference was statistically significant(F=3.435,P<0.05).The levels of LDL in SGA group and(FGA+SGA)group were 2.51±0.39mmol/L and 2.42±0.46mmol/L,respectively,which were also higher than those in FGA group 2.35±0.61mmol/L,and the difference was statistically significant(F=3.231,P<0.05).Conclusion The second generation antipsychotics alone and combination therapy are more likely to cause lipid metabolism abnormality than the first generation antipsychotics alone in first-episode schizophrenia.

作者谭梅娟李靖 TAN Mei-juan;LI Jing(Brain Hospital of Hunan Province,Changsha 410007,China;the First Hospital of Changsha,Changsha 410005,China)

机构地区湖南省脑科医院长沙市第一医院

出处《现代检验医学杂志》 CAS 2019年第2期91-93,99,共4页 Journal of Modern Laboratory Medicine

基金湖南省自然科学基金项目(2015JJ6084) 湖南省卫生计生委科研基金课题(B2015-105)

关键词抗精神病药血脂代谢首发精神分裂症 antipsychotic agents lipid metabolism first-episode schizophrenia

分类号 R749.3 [医药卫生—神经病学与精神病学] R446.112 [医药卫生—诊断学]

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