摘要
目的研究29 d至3月龄住院婴儿急性下呼吸道感染(acute lower respiratory tract infection,ALRTI)的病原分布及临床特征,为临床合理用药提供参考。方法选取2016年12月至2019年12月北京新世纪儿童医院住院的29 d至3月龄诊断为ALRTI的患儿506例,总结各种病原的分布情况,分析不同季节病原分布特点,比较单纯呼吸道合胞病毒(respiratory syncytial virus,RSV)感染与RSV合并细菌感染的临床特点。结果共357例患儿检出阳性病原,阳性率70.6%。病原检出顺序依次为RSV、金黄色葡萄球菌、大肠埃希菌、肺炎克雷伯菌等。RSV为最常见病毒病原,金黄色葡萄球菌为最常见细菌病原。常见病原检出率冬季最高(P<0.05),且RSV在冬季检出率最高,而肺炎克雷伯菌在秋季检出率最高。单纯RSV感染和RSV合并细菌感染临床特点比较差异无统计学意义(P>0.05)。结论29 d至3月龄住院婴儿ALRTI病原种类多,病原阳性率70.6%,常见病原为RSV、金黄色葡萄球菌、大肠埃希菌等。RSV为主要病毒病原,金黄色葡萄球菌为主要细菌病原,病原检出率冬季最高。RSV合并细菌感染时,混合细菌可能为呼吸道定植菌,临床应结合患儿症状及疗效综合判断并合理用药。
Objective To study the pathogens distribution and the clinical features of acute lower respiratory tract infection(ALRTI)in infants aged from 29 days to three months in Beijing New Century Children’s Hospital,so as to provide references for clinical application of drugs.Methods Five hundred and six cases of hospitalized infants aged from 29 days to three months with ALRTI from December 2016 to December 2019 were collected.The basic distribution of pathogens,the distribution of pathogens in different seasons,and the clinical characteristics of respiratory syncytial virus(RSV)and RSV mixed bacteria infection were analyzed.Results Five hundred and six cases of infants were examined for pathogens,357 cases were positive,the positive rate was 70.6%.The sequence of pathogen detection was RSV,SA,Escherichia Coli,Klebsiella pneumoniae,Streptococcus pneumoniae etc.RSV was the most common viral pathogen,and SA was the most common bacterial pathogen.The detection rate of common pathogens was the highest in winter(P<0.05),the detection rate of RSV was the highest in winter,and the detection rate of Klebsiella pneumoniae was the highest in autumn.Comparison of clinical characteristics of RSV infection and RSV mixed bacterial infection showed no significant difference between the two groups(P>0.05).Conclusions There are many pathogens of ALRTI in infants aged from 29 days to three months in our hospital,and the positive rate of pathogens is 70.6%.The common pathogens are RSV,SA,Escherichia Coli and so on.RSV is the main viral pathogen,and SA is the main bacterial pathogen.The pathogen detection rate is highest in winter.When RSV is mixed with bacteria infection,the mixed bacteria may be the respiratory colonization bacteria.The clinical judgment should be combined with the symptoms and treatment effect of children and rational drug use.
作者
郑琪
王阳
刘金荣
王琳琳
刘浩
Zheng Qi;Wang Yang;Liu Jinrong;Wang Linlin;Liu Hao(Department of Pediatric Internal Medicine,Beijing New Centry Children's Hospital,Beijing 100045,China)
出处
《北京医学》
CAS
2021年第2期138-141,共4页
Beijing Medical Journal
关键词
急性下呼吸道感染
呼吸道病原
临床特点
婴儿
acute lower respiratory tract infection(ALRTI)
respiratory pathogens
clinical features
infant
