摘要
目的:分析3种机型血细胞分离机Amicus、Trima和Mcs+采集血小板活化和功能的差异。方法:选择2019年单采血小板的献血者60例,按照3种机型所有献血者被随机分成3组,每组各20例。检测各组采集血小板活化指标PAC-1、CD62P和用血栓弹力图评估功能,进行统计分析。结果:3种机型采集血小板活化指标CD62P均高于正常值,Amicus采集血小板活化指标CD62P和PAC-1较另2种血细胞分离机比较差异有统计学意义(P<0.05)。3种机型血小板功能指标和血小板计数比较差异无统计学意义(P>0.05)。结论:3种机型血细胞分离机采集的血小板,均存在一定程度血小板活化;不同分离方式所采集的单采血小板其活化程度之间存在差异。
Objective:To analyze the differences of platelet activation and function among Amicus,TrimA and MCS +blood cell separator. Methods:60 cases of platelet donors in 2019 were selected.They were randomly divided into 3 groups according to the three machine models,with 20 cases in each group.The platelet activation indexes PAC-1 and CD62 p were detected in each group.In addition,thromboelastography was used to evaluate platelet function.These data were statistical analyzed. Results:The platelet activation index CD62 P collected by three models was higher than the normal value.The platelet activation indexes CD62 P and PAC-1 collected by Amicus were significantly different from the other two blood cell separators(P<0.05).There was no significant difference in platelet function index and platelet count among the three groups(P>0.05).Conclusion:Platelets collected by three types of blood cell separators are activated to a certain extent.There are differences in the activation levels of apheresis platelets collected by different separation methods.
作者
姚勇
张欢欢
孙振超
吴运萍
唐梦怡
YAO Yong;ZHANG Huanhuan;SUN Zhenchao;WU Yunping;TANG Mengyi(Lianyungang Red Cross Blood Center of Jiangsu Province,Lianyungang,222001,China;Department of Laboratory Medicine,Lianyungang First People’s Hospital;Department of Blood Transfusion,Second People’s Hospital of Lianyungang City)
出处
《临床血液学杂志》
CAS
2021年第2期127-129,共3页
Journal of Clinical Hematology
基金
江苏省输血协会英科新创科研基金(No:Js2018004)。
关键词
血细胞分离机
单采血小板
血小板活化
血小板功能
血小板输注
blood cell separator
apheresis platelets
platelet activation
platelet function
platelet transfusion
