摘要
目的:探讨腕关节镜手术联合非布司他治疗痛风性腕关节炎的效果及对血清炎性因子和氧化应激状态的影响。方法:根据治疗方案的不同,将80例痛风性腕关节炎患者分为观察组(腕关节镜手术联合非布司他治疗)和对照组(腕关节镜手术治疗),每组各40例。比较两组治疗后的临床疗效,检测两组治疗前后实验室指标(SUA、TC、TG、HDL和LDL)、炎性因子血清白细胞介素1(IL-1)、白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)及氧化应激指标血清8-羟基脱氧鸟苷(8-OHdG)、丙二醛和3-硝基络氨酸修饰蛋白(3-NT)水平。结果:观察组总有效率高于对照组(P<0.05)。治疗前,两组SUA、TC、TG、HDL和LDL水平比较,差异无统计学意义(P>0.05);治疗后,观察组血清SUA水平低于对照组(P<0.05),观察组TC、TG、LDL水平相比治疗前降低,HDL上升,且与对照组比较差异均有统计学意义(P<0.05);对照组TC、TG、HDL和LDL水平相比治疗前,差异无统计学意义(P>0.05)。治疗前,两组IL-1、IL-6、TNF-α、8-OHdG、丙二醛和3-NT水平比较,差异无统计学意义(P>0.05);治疗后,两组IL-1、IL-6、TNF-α、8-OHdG、丙二醛和3-NT水平均降低,且观察组低于对照组(P<0.05)。结论:腕关节镜手术联合非布司他治疗痛风性腕关节炎疗效显著,并能有效改善血脂代谢,减轻炎症反应和氧化应激状态。
Objective:To investigate the effect of carpal arthroscopy combined with febuxostat in the treatment of gout carpal arthritis and its effect on serum inflammatory factors and oxidative stress.Methods:A total of 80 patients with gout carpal arthritis were selected as study subjects.According to different treatment regiments,they were divided into observation group(carpal arthroscopic surgery combined with febuxostat,n=40)and control group(carpal arthroscopic surgery,n=40).The clinical effect of the two groups after treatment was compared.Laboratory indexes(SUA,TC,TG,HDL and LDL),inflammatory cytokines serum interleukin 1(IL-1),interleukin 6(IL-6),αtumor necrosis factor(TNF-α)and oxidative stress indicators 8-hydroxy serum deoxyguanosine(8-OHdG),malondialdehyde and 3-nitro complex amino acid modified protein(3-NT)level of the two groups before and after treatment were detected.Results:The total effective rate in the observation group was significantly higher than that in the control group(P<0.05).Before treatment,SUA,TC,TG,HDL and LDL levels were not significantly(P>0.05).After treatment,the SUA level of the observation group was lower than that of the control group(P>0.05).The levels of TC,TG and LDL in the observation group were lower than those before treatment,while HDL was higher than before treatment,and compared with the control group,the difference was statistically significant(P<0.05).There was no significant difference in the levels of TC,TG,HDL and LDL in the control group before and after treatment(P>0.05).Before treatment,there was no significant difference in IL-1,IL-6,TNF-α,8-OHdG,malondialdehyde and 3-NT levels between the two groups(P>0.05).After treatment,the levels of IL-1,IL-6,TNF-α,8-OHdG,malondialdehyde and 3-NT in both groups were decreased,and those in the observation group were lower than those in the control group(P<0.05).Conclusion:Carpal arthroscopy combined with febuxostat is effective in the treatment of gout carpal arthritis,and can effectively improve blood lipid metabolism,reduce inflammation and oxidative stress.
作者
向往
杨顺
程亚博
陈柯屹
XIANG Wang;YANG Shun;CHENG Ya-bo;CHEN Ke-yi(Department of Wrist,Sichuan Provincial Orthopaedic Hospital,Chengdu 610041,Sichuan,China)
出处
《川北医学院学报》
CAS
2021年第4期492-496,共5页
Journal of North Sichuan Medical College
基金
成都中医药大学校基金医院专项(YYZX2018005)。
关键词
痛风性腕关节炎
腕关节镜手术
非布司他
炎症反应
氧化应激
Gouty carpal arthritis
Wrist arthroscopic surgery
Febuxostat
Inflammatory response
Oxidative stress
