摘要
颗粒物(particulate matter,PM)是空气污染物中的主要成分,可以通过多种途径进入肠道。研究证实颗粒物进入肠道能够增加肠上皮的通透性,降低肠道免疫屏障功能,也可被代谢为有毒产物进一步引起肠道损伤。颗粒物还能够改变肠道微生物群的组成,目前认为微生物群和机体多个系统的功能密切相关。颗粒物引发的肠道炎症反应影响全身多系统的健康。本文综述了近年来关于空气颗粒物造成的肠道微生物群改变、肠道损伤及其引起的肠道免疫应答反应的研究进展,阐明空气颗粒物进入肠道可能对人体健康产生的影响,为治理空气污染进而改善人群健康提供理论依据。
Particulate matter is an important component of air pollutants and can enter intestinal tract through a variety of ways.Particulate matter entering intestinal tract has been proved to increase intestinal epithelial permeability and impair intestinal immune barrier function,and can also be metabolized into toxic products to further cause intestinal injury.Particulate matter can also alter the composition of intestinal microbiota,which is thought to be closely related to the functions of multiple systems in the body.Particulate matter triggers an inflammatory reaction in the gut that can lead to further health problems throughout the body.In this paper,the progress in recent research on the changes in intestinal microbiota or intestinal injury caused by airborne particles and the intestinal immune response caused by airborne particles is reviewed,and the possible effects of airborne particles on human health via intestinal tract are clarified,so as to provide theoretical basis for the treatment of air pollution and the improvement of human health.
作者
邓露
王海
潘一箫
郭晓奎
刘畅
DENG Lu;WANG Hai;PAN Yi-xiao;GUO Xiao-kui;LIU Chang(Department of Immunology and Microbiology,School of Medicine,Shanghai Jiao Tong University,Shanghai 200025,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2021年第3期356-360,共5页
Chinese Journal of Microecology
基金
国家自然科学基金(31400001)。
