摘要
原发性耳鸣的发病机制与多个脑网络中不同脑区的神经可塑性改变密切相关。由于长期异常信号的输入,细胞膜发生变化,突触活动发生改变,造成神经敏感性改变,逐渐引起中枢神经元的重塑。视觉网络、听觉网络、默认网络的各个脑区的中枢可塑性改变可能是耳鸣形成和维持的原因。西医、中医、中西医结合治疗均可改变各脑网络中不同脑区的神经兴奋性与不同脑区之间的连接,通过调整中枢可塑性改善耳鸣症状。这种中枢可塑性的变化可以通过新兴的神经影像学的技术进行观察。
Pathogenesis of primary tinnitus is closely related to plasticity changes in different brain regions of multiple neural networks.Long-term abnormal signal input causes changes in cell membrane and synaptic activities,resulting in changes of neural sensitivity and remodeling of neural centers.The formation and maintenance of tinnitus may be due to plasticity changes in the visual,auditory as well as the default mode networks.Scholars have proposed different neural function models for tinnitus.Excitability of different brain regions and their connections can be modulated by western medicine,traditional Chinese medicine and integrated Chinese and Western medicine approaches,aimed at modulating brain plasticity.Changes in brain plasticity can be observed using latest neuroimaging technologies.
作者
周晶莹
许铭
沈卫东
ZHOU Jingyin;XU Ming;SHEN Weidong(Shanghai University of Traditional Chinese Medicine Shuguang Hospital,Shanghai 200120;Shanghai Jiading District Central Hospital,Shanghai 201800)
出处
《中华耳科学杂志》
CSCD
北大核心
2021年第2期328-331,共4页
Chinese Journal of Otology
基金
上海市科委科研基金项目(16401970402)
上海市卫健委科研项目(2016LP046)
上海市进一步加快中医药事业发展三年行动计划项目[ZY(2018-2012)-CCCX-1005]。
