摘要
目的研究T细胞相关炎症因子与帕金森病发病的关系。方法纳入41例确诊的早期PD患者(病程<5年、Hoehn-Yahr分期≤Ⅱ期),选择39例年龄、性别匹配的非神经变性病患者作为对照,测定两组外周血中T细胞相关炎症因子如白细胞介素-17A(IL-17A)、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、干扰素-γ(IFN-γ)、白细胞介素-12p70(IL-12p70)、白细胞介素-23(IL-23)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、干扰素-α(IFN-α)等水平,并进行比较。结果PD组外周血中IL-6、IFN-α、IL-12p70水平高于对照组,IL-17A水平明显低于对照组(均P<0.05)。结论T细胞相关炎症因子与帕金森病关系密切,可能参与帕金森病发病机制。
Objective To study the relationship between T cell related inflammatory factors and Parkinson's disease(PD).Methods 41 PD patients with disease duration less than 5 years and Hoehn Yahr stage≤Ⅱwere included in the PD group.Beside,we selected 39 patients with neurodegerative disease as controls.We measured and compared T cell related inflammatory factors in the peripheral blood of the two groups,such as IL-17A IL-10,IL-6,IFN-γ,IL-12p70,IL-23,TNF-α,IL-1β,IFN-αand so on.Results The levels of IL-6,IFN-a and IL-12p70 in the PD group were higher than those in the control group(all P<0.05),and the level of IL-17A in the PD group was lower than that in the control group(P<0.05).Conclusions T cell related inflammatory factors are closely related to PD,and may be involved in the pathogenesis of PD.
作者
许吉怡
赵程
王铁山
徐筱青
时晶
秦斌
XU Jiyi;ZHAO Cheng;WANG Tieshan;XU Xiaoqing;SHI Jing;QIN Bin(不详;Department of Neurology,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中国神经免疫学和神经病学杂志》
CAS
北大核心
2021年第2期131-133,145,共4页
Chinese Journal of Neuroimmunology and Neurology
基金
北京医院社会团体基金(BJ-2018-094)。
关键词
帕金森病
外周血
炎症因子
T细胞
Parkinson's disease
peripheral blood
inflammatory factors
T cell
