摘要
目的 探讨职业应激对血清中肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1β、IL-2和IL-4的影响.方法 采用横断面研究方法对200名电冰箱厂装配线生产工人进行调查,收回有效问卷169份.使用修订的工作紧张模式问卷、付出-回报失衡模式问卷和职业应激测量工具测试职业应激因素、个性特征、应激反应及缓解因素;采用放射免疫法或酶免疫法检测血清中各生化指标的表达水平.结果 情感平衡高水平组和对照组间血清中TNF-α浓度[（1.947±0.173）和（2.029±0.240）fmol/ml]的差异有统计学意义（P＜0.05）,外在付出高水平组和对照组间血清中IL-1β浓度[（0.133±0.034）和（0.118±0.031）ng/ml]的差异有统计学意义（P＜0.05）,回报[（1.514±0.406）和（1.665±0.369）ng/ml]、角色模糊[（1.658±0.376）和（1.491±0.033）ng/ml]、角色冲突[（1.774±0.311）和（1.589±0.380）ng/ml]和每日紧张感[（1.759±0.361）和（1.606±0.381）ng/ml]高水平组和对照组间血清中IL-2浓度的差异有统计学意义（P＜0.05）;回报高水平组和对照组间血清中IL-4浓度[（1.449±0.025）和（1.466±0.041）pg/ml]的差异有统计学意义（P＜0.05）.多元逐步回归分析结果显示,情感平衡是血清中TNF-α浓度的预测因子（R2值为0.029）,外在付出和心理卫生是血清中IL-1β浓度的预测因子（R2值分别为0.029和0.055）,角色冲突、每日紧张感和角色模糊是血清中IL-2浓度的预测因子（R2值分别为0.040,0.078和0.104）,回报是血清中IL-4浓度的预测因子（R2值为0.030）.结论 不良的社会心理应激因素可能导致血清中TNF-α及IL-1β、IL-2、IL-4浓度升高.
Objective To explore the effect of occupational stress on serum tumor necrosis factor-α （TNF-α）, interleukin（IL）- 1β, IL-2 and IL-4.Methods A cross-sectional epidemiological study was conducted in 200 workers from the refrigerator assembly line in Henan province in China.Psychosocial work conditions were measured by using the job demand-control model, the effort-reward imbalance model questionnaires and occupational stress measurement scale.Serum TNF-α, IL-1β, IL-2, and IL-4 concentrations were measured by radioimmunoassay or immunoradiometricassay method respectively.Results Serum TNF-α concentration was statistically significantly different between workers with higher affective balance level and control groups[（1.947±0.173）and（2.029±0.240）fmol/ml]（P＜0.05）.Serum IL-1β concentration was statistically significantly different between workers with higher effort level and control groups[（0.133 ±0.034）and（0.118 ±0.031）ng/ml]（P＜0.05）.Serum IL-2 concentration was statistically significantly different between workers with higher role ambiguity level[（1.658±0.376）and（1.491±0.033）ng/ml]and control groups（P＜0.05）, as well as between workers with higher role conflict level and control groups[（1.774±0.311）and（1.589±0.380）ng/ml]（P＜0.05）, between workers with higher daily life stress level and control groups[（1.759±0.361）and（1.606±0.381）ng/ml]（P＜0.05）.Serum IL-4 concentration was statistically significantly different between workers with higher reward level and control groups[（1.449±0.025）and（1.466±0.041）pg/ml]（P＜0.05）.Stepwise regression analysis indicated that affective balance was the predictor of serum TNF-α（R2=0.029）.Effort and mental health were the predictors of serum IL-1β（R2 was 0.029 and 0.055, respectively）.Role conflict, daily life stress and role ambiguity were the predictors of serum IL-2（R2 was 0.040, 0.078 and 0.104, respectively）.Reward was the predictor of serum IL-4（R2=0.030）.Conclusion Unhealthy psychological stress factor might be induce a marked increase in the concentrations of serum TNF-α, IL-1β, IL-2, as well as IL-4.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2010年第12期904-908,共5页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
河南省医学科技创新人才工程计划项目（2004-62）
河南省2010年度医学科技攻关计划项目（201001009）
