摘要
目的探讨罗伊氏乳杆菌(息敏乐)辅助治疗儿童功能性便秘的临床疗效及安全性,为后续研究提供参考。方法选择2016年6月至2018年6月期间5个研究中心收治的237例功能性便秘患儿为研究对象,按照随机数表法分为对照组(n=76)、观察A组(n=78)、观察B组(n=83)。对照组患儿采用饮食调节及排便习惯锻炼等常规治疗,观察组患儿在此基础上加用息敏乐治疗,其中观察A组剂量为1次/d,观察B组剂量为2次/d,3组患儿均持续治疗4周并随访2个月。对比3组患儿治疗后总有效率、大便性状评分、排便困难评分、每周排便次数、排便时间、排便间隔、粪便pH值、肠道菌群变化、复发率及不良反应情况。结果治疗后观察B组患儿的总有效率(93.98%)明显高于对照组(80.26%)及A组(85.90%),每周排便次数及肠道乳杆菌数量多于对照组及A组,排便时间短于对照组,排便间隔短于对照组及A组,粪便性状评分、排便困难评分、粪便pH值、肠道产气夹膜梭菌、肠球菌、肠杆菌数量及复发率明显低于对照组及A组(均P<0.05)。3组患儿不良反应发生率差异无统计学意义(P>0.05)。结论罗伊氏乳杆菌辅助治疗可调节功能性便秘患儿肠道菌群平衡,疗效显著,患儿不易复发,安全性较高。
Objective To explore the clinical efficacy and safety of Lactobacillus reuteri(Xi-min-le) in the adjuvant treatment of functional constipation in children and provide a reference for following study. Methods A total of 237 child patients with functional constipation admitted to the five research centers from June 2016 to June 2018 were enrolled and divided into observation group A(n=78), observation group B(n=83)or control group(n=76)randomly.All the groups were given conventional treatments of diet regulation and bowel habits exercise,while the two observation groups were additionally given Xi-min-le(qd in group A and bid in group B);the three groups were treated for 4 weeks and followed up for 2 months.The total efficiency rate, stool trait score, defecation difficulty score, weekly defecation frequency, defecation time, defecation interval, stool PH value, intestinal flora changes, recurrence rate and adverse reactions were compared among the three groups after treatment. Results The total efficiency rate in observation group B(93.98%) was significantly higher than that in control group(80.26%) and observation group A(85.90%). In the observation group B, the weekly defecation frequency and intestinal Lactobacilli number were higher than those in control group and observation group A;the defecation time was shorter than that in control group;the defecation interval was shorter than that in control group and observation group A;the stool trait score, defecation difficulty score,pH value,numbers of Clostridium perfringens,Enterococcus and Enterobacteriaceae, and recurrence rate were significantly lower than those in control group and observation group A(all P<0.05). There was no significant difference in the incidence rate of adverse reactions among the three groups(P>0.05). Conclusion Lactobacillus reuteri can help regulate the balance of intestinal flora in children with functional constipation with remarkable efficacy,low recurrence rate and good safety.
作者
季施燕
拾景梅
赵虬旻
孙菊娣
蒋平
冯罗华
周承
JI Shi-yan;SHI Jing-mei;ZHAO Qiu min;SUN Ju-di;JIANG Ping;FENG Luo-hua;ZHOU Cheng(Department of Gastroenterology,the Affiliated Changzhou Children′s Hospital of Nantong University,Changzhou,Jiangsu213003,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2021年第2期178-182,共5页
Chinese Journal of Microecology
关键词
功能性便秘
儿童
罗伊乳杆菌
Functional constipation
Children
Lactobacillus reuteri
