摘要
目的探讨心力衰竭标志物可溶性生长刺激表达因子2(sST2)替代N末端B型脑钠肽前体(NTproBNP)评价心脏术后肾功能不全患者心功能变化的临床价值。方法选择2019年1~6月我科心脏外科手术后肾功能不全患者60例作为试验组,其中男34例、女26例,平均年龄49~78(63.3±4.5)岁;另选取心脏术后肾功能正常患者60例作为对照组,其中男37例、女23例,平均年龄53~77(61.7±3.8)岁。比较两组患者围手术期左心室射血分数、心肌肌钙蛋白、肌酸肌酶、sST2及NT-proBNP等心功能指标。结果试验组患者围手术期NTproBNP显著升高,其变化幅度与其它心功能指标变化幅度差异有统计学意义,不能够准确反映术后心功能的变化程度。而sST2变化幅度与其它心功能指标变化幅度相近,基本能够反映心功能的变化程度。结论在心脏术后肾功能不全患者中,采用心力衰竭标志物sST2替代NT-proBNP作为心功能评价指标,可以真实准确地反映心功能变化程度,其优势明显,具有重要的临床价值。
Objective To explore the clinical value of soluble suppression of tumorigenesis-2(sST2)in replacement of N-terminal fragment of the brain natriuretic peptide precursor(NT-proBNP)in cardiac function evaluation in renal failure patients after cardiac surgery.Methods Sixty patients with renal insufficiency after cardiac surgery from January 2019 to June 2019 were divided into a test group,including 34 males and 26 females,with an average age of 49-78(63.3±4.5)years.Another 60 patients with normal renal function were divided into a control group,including37 males and 23 females,with an average age of 53-77(61.7±3.8)years.The perioperative left ventricular ejection fraction,cardiac troponin T,creatine kinase-MB,sST2 and NT-proBNP were compared.Results In patients of the test group,the NT-proBNP level increased significantly during perioperative period,and the change range was different from other cardiac function indexes.The change of sST2 in perioperative period was similar to other cardiac function indexes,which could reflect the change degree of cardiac function after operation.Conclusion sST2 is more important to reflect the change degree of cardiac function in patients with renal dysfunction after cardiac surgery than NT-proBNP.
作者
赵东
吴波
沈金强
王春生
ZHAO Dong;WU Bo;SHEN Jinqiang;WANG Chunsheng(Department of Cardiac Surgery,Zhongshan Hospital,Fudan University,Shanghai,200032,P.R.China;Department of Cardiology,Yangpu Hospital,Tongji University,Shanghai,200082,P.R.China)
出处
《中国胸心血管外科临床杂志》
CSCD
北大核心
2021年第3期331-334,共4页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
