摘要
目的探讨可溶性生长刺激表达基因2蛋白(sST2)联合晚期钆增强(LGE)在非缺血性扩张型心肌病(NIDCM)患者预后中的应用。方法选取2021年1月至2024年4月江苏省人民医院133例非缺血性扩张型心肌病患者作为研究对象。收集患者临床资料,对所有患者实施晚期钆增强⁃心脏磁共振(LGE⁃CMR)扫描。根据随访结果分为主要心血管不良事件(MACE)组(n=17)和非MACE组(n=116),对比两组临床资料、sST2、LGE评分情况。COX回归分析血清sST2、LGE评分与NIDCM患者预后的关系。绘制受试者工作特征曲线(ROC)评估血清sST2、LGE评分对NIDCM患者预后的预测价值。结果MACE组血清sST2、LGE显著高于非MACE组,差异有统计学意义(P<0.05)。COX回归提示血清sST2、LGE升高是NIDCM患者预后不良的危险因素(P<0.05)。ROC曲线发现血清sST2、LGE评分联合预测NIDCM患者预后的敏感度为0.733,特异度为0.839,曲下线面积(AUC)为0.824,均高于二者单独预测。结论sST2、LGE与NIDCM患者预后存在密切联系,二者联合应用在NIDCM患者预后评估中具有重要预测价值。
Objective To explore the application of soluble growth⁃stimulating gene expression 2 protein(sST2)combined with late gadolinium enhancement(LGE)in the prognosis of patients with non⁃ischemic dilated cardiomyopathy(NIDCM).Methods A total of 133 patients with non⁃ischemic dilated cardiomyopathy at Jiangsu Provincial People's Hospital from January 2021 to April 2024 were selected as research subjects.The patients'clinical data were collected,and late gadolinium enhancement⁃cardiac magnetic resonance(LGE⁃CMR)scanning was performed on all of them.Based on the follow⁃up results,the patients were divided into a major adverse cardiovascular event(MACE)group(n=17)and a non⁃MACE group(n=116).The clinical data,sST2,and LGE scores of both groups were compared.COX regression analysis was used to analyze the relationship between serum sST2 levels,LGE scores,and the prognosis of NIDCM patients.A receiver operating characteristic(ROC)curve was plotted to evaluate the predictive value of serum sST2 levels and LGE scores for the prognosis of NIDCM patients.Results The serum sST2 levels and LGE scores in the MACE group were significantly higher than those in the non⁃MACE group,and the difference was statistically significant(P<0.05).Elevated serum sST2 levels and LGE scores were identified as risk factors for poor prognosis in NIDCM patients(P<0.05).The sensitivity of serum sST2 levels and LGE scores in predicting the prognosis of NIDCM patients was 0.733,the specificity was 0.839,and the area under the curve(AUC)was 0.824,all of which were higher than the prediction of the two biomarkers alone.Conclusion There is a close relation⁃ship between sST2 levels and LGE scores in NIDCM patients,and the combined application of the two has important value in evaluating the prognosis of these patients.
作者
周阔
周宁天
吴丹
魏赟晨
占伊扬
ZHOU Kuo;ZHOU Ningtian;WU Dan;WEI Yunchen;ZHAN Yiyang(Department of Cardiovascular Medicine,Nanjing,Jiangsu,China,210029;Department of Geriatrics,the First Affiliated Hospital of Nanjing Medical University(Jiangsu Provincial People's Hospital),Nanjing,Jiangsu,China,210029;Department of General Practice,Zhonghua Road Community Health Service Center,Qinhuai District,Nanjing,Nanjing,Jiangsu,China,210001)
出处
《分子诊断与治疗杂志》
2025年第1期21-25,共5页
Journal of Molecular Diagnostics and Therapy
基金
江苏基层卫生发展与全科医学教育研究中心开放课题(2020A01)。
关键词
非缺血性扩张型心肌病
晚期钆增强
可溶性生长刺激表达基因2蛋白
预后
Non-ischemic dilated cardiomyopathy
Advanced gadolinium enhancement
Soluble growth stimulation gene 2 protein
Prognosis
