摘要
目的探讨冠心病患者血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、同型半胱氨酸(homocysteine,Hcy)和胱抑素C(cystatin C,Cys C)的水平及临床意义。方法选取2017年3月—2019年12月在郑州人民医院心内科就诊135例冠心病患者作为病例组,行冠状动脉造影检查后根据冠状动脉狭窄程度分为轻度狭窄组(39例)、中度狭窄组(61例)和重度狭窄组(35例),选取同期在医院进行健康体检的100例研究对象作为对照组。所有研究对象均采用免疫荧光法检测血清hs-CRP水平,Elisa法检测血清Hcy水平,免疫投射比浊法检测血清Cys C水平冠状动脉,并进行冠状动脉Gensini评分。比较病例组与对照组以及不同冠状动脉狭窄组之间血清学相关指标的差异,以及各血清学指标水平与冠状动脉Gensini评分之间的关系。结果病例组患者血清hs-CRP(9.53±2.16)mg/L、Hcy(19.75±3.89)μmol/L以及Cys C(2.20±0.52)mg/L水平均高于对照组,差异有统计学意义(P<0.05);病例组患者各组间血清hs-CRP、Hcy以及Cys C指标水平的差异有统计学意义(P<0.05),并且中度狭窄组患者上述指标水平高于轻度狭窄组,重度狭窄组患者上述指标水平高于轻度狭窄组和中度狭窄组,差异均有统计学意义(P<0.05);病例组患者血清hs-CRP、Hcy和Cys C指标均与冠状动脉Gensini评分呈明显正相关关系,r值分别为0.547、0.430和0.469,差异均有统计学意义(P<0.05)。结论冠心病患者血清hs-CRP、Hcy以及Cys C等指标水平异常增高,并且与冠状动脉狭窄病变的严重程度存在密切关系。
Objective To explore the clinical significance of serum levels of hypersensitive C-reactive protein(hs-CRP), homocysteine(Hcy) and cystatin C(Cys C) in patients with coronary heart disease.Methods A total of 135 patients with coronary heart disease admitted to Zhengzhou People’s Hospital from March 2017 to December 2019 were selected as the case group, and divided into mild stenosis group(39 cases), moderate stenosis group(61 cases) and severe stenosis group(35 cases) according to the degree of coronary artery stenosis. 100 healthy subjects were selected as the control group in the same period. The serum levels of hs-CRP were detect by immunofluorescence method, Hcy were detect by Elisa, Cys C were detect by turbidimetry, and the coronary artery Gensini scores were detect. The serological related indicators of hs-CRP, Hcy and Cys C were compared between the case group and the control group, and compared among different coronary artery stenosis groups. The relationship between the levels of serological related indexes and the coronary artery Gensini score was analyzed.Results The serum levels of hs-CRP(9.53±2.16)mg/L, Hcy(19.75±3.89)μmol/L and Cys C(2.20±0.52)mg/L in the case group were significantly higher than those in the control group(P<0.05). There were significant differences in serum levels of hs-CRP, Hcy and Cys C among the patients in the case group(P<0.05). The levels of above-mentioned indicators in the moderate stenosis group were significantly higher than those of the mild stenosis group, and the levels in the severe stenosis group were significantly higher than those of the mild stenosis group and moderate stenosis groups(P<0.05). The serum indicators levels ofhs-CRP, Hcy and Cys C in the case group were significantly positively correlated with the coronary artery Gensini score, and r=0.547, 0.430 and 0.469, respectively(P<0.05).Conclusion The serum levels of hs-CRP, Hcy and Cys C in patients with coronary heart disease were abnormally increased, and the above-mentioned indicators were closely related to the severity of coronary artery stenosis.
作者
张朝华
刘旭帮
汤建民
ZHANG Chao-hua;LIU Xu-bang;TANG Jian-min(Department of Cardiology,Zhengzhou Peoples Hospital,Zhengzhou 450000,China;不详)
出处
《医药论坛杂志》
2021年第2期71-74,共4页
Journal of Medical Forum
关键词
冠心病
超敏C反应蛋白
同型半胱氨酸
胱抑素C
冠状动脉狭窄
Coronary heart disease
Hypersensitive C-reactive protein
Homocysteine
Cystatin C
Coronary artery stenosis
