摘要
目的探讨食管鳞状细胞癌O^(6)-甲基鸟嘌呤DNA甲基转移酶(MGMT)表达与CT影像及临床病理特征之间的关系。方法回顾性分析142例手术切除的食管鳞状细胞癌术前胸部平扫及增强CT图像,测量病灶CT值、轴位最大厚度及垂直径,记录临床病理特征。分类资料采用χ^(2)检验或Fisher精确检验。采用独立样本t检验或Mann-Whitney U检验用于比较MGMT不同表达状态间CT参数的差异。采用ROC曲线分析CT参数在预测MGMT不同表达状态时的效能,Spearman分析MGMT表达与CT参数间的相关性。结果病理总分期、增强CT及ΔCT、最大厚度在MGMT不同表达状态组间差异有统计学意义(P均<0.05)。增强CT及ΔCT鉴别MGMT不同表达状态时的诊断效能较优,曲线下面积分别为0.810、0.817,且增强CT及ΔCT与MGMT表达的相关性较高(r=-0.444、-0.473,P均<0.05)。结论MGMT异常表达可能参与食管鳞状细胞癌的发生与发展过程,术前肿瘤增强CT及ΔCT值可较好的预测MGMT表达状态,对评估肿瘤发展及选择合适的治疗方案具有一定临床辅助价值。
Objective To investigate the correlation between O^(6)-methylgua-nine-DNA methyltransferase(MGMT)expression and CT imaging,clinicopathological features of esophageal squamous cell carcinoma(ESCC).Methods Non-enhanced and enhanced thoracic CT images of 142 cases for ESCC were retrospectively analyzed preoperatively.CT values,maximum axial thickness and vertical diameter of lesions were measured,and clinicopathological features were recorded.Categorical variable was tested using theχ^(2)test or Fisher's exact test.Independent-samples t test or Mann-Whitney U test was applied to compare the differences in CT parameters between different MGMT expression status.Receiver operating characteristic(ROC)curve was used to analyze the effectiveness of CT parameters in predicting different expression status of MGMT and Spearman was used to analyze the correlation between MGMT expression and CT parameters.Results There were significant differences in total pathological stage,enhanced CT,ΔCT and maximum thickness among different MGMT expression groups(all P<0.05).The diagnostic efficiency of enhanced CT and ΔCT values in differentiating different expression states of MGMT was higher,with AUC of 0.810,0.817,respectively.There was a high correlation between the enhanced CT,ΔCT values and MGMT expression(r=-0.444,-0.473,P<0.05).Conclusion Abnormal expression of MGMT may be involved in the development and progression of ESCC.Preoperative tumor enhanced CT values can better predict the expression status of MGMT,which has auxiliary value for evaluating development of tumor and selecting appropriate treatment scheme.
作者
张海龙
郑欢欢
周科峰
ZHANG Hailong;ZHENG Huanhuan;ZHOU Kefeng(Department of Radiology,Nanjing Drum Tower Hospital,The Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处
《分子影像学杂志》
2021年第1期53-58,共6页
Journal of Molecular Imaging
基金
南京市卫计委医学科技发展项目(YKK17073)
十三五南京市卫生青年人才培养工程第二层次项目(QRX17056)。
