摘要
心血管疾病是引起全球人口死亡的主要原因,中国心血管疾病患病率持续上升。多数心血管疾病的发生和发展与血管自稳态失衡、血管不良重构有关。运动可以保护心血管健康,参与调节血管稳态及良性重构。基于运动的心血管保护效应,深入了解血管稳态及血管重构的分子机制,对发掘血管重构相关的心血管疾病的治疗药物、防治重大心血管不良事件具有重要的指导意义。围绕运动保护血管稳态与重构的分子机制,对血管不良重构的潜在靶点及生物药物的研发进展进行综述,以期为相关药物的研发提供新的思路和理论指导。
Cardiovascular diseases are the leading cause of death worldwide,and their rate of morbidity is continuously increasing in China.The occurrence and progression of most cardiovascular diseases are associated with the imbalance of vascular homeostasis and adverse vascular remodeling.Exercise protects cardiovascular health and is involved in regulating vascular homeostasis.Based on the cardiovascular protective effect of exercise,in-depth understanding of the molecular mechanism of vascular homeostasis and vascular remodeling is of great significance for guiding the exploration of the therapeutic drugs for vascular remodeling and major cardiovascular adverse events.In the present article,the molecular mechanism of vascular homeostasis and remodeling based on exercise-induced cardiovascular protection was addressed,and the potential biological drugs for treating adverse vascular remodeling as well as their development were reviewed,aiming to provide new direction and theoretical guidance for the research and development of related drugs.
作者
王红云
谢玉玲
高娟
肖俊杰
WANG Hongyun;XIE Yuling;GAO Juan;XIAO Junjie(Shanghai University Institute of Cardiovascular Sciences,School of Medicine,Shanghai University,Shanghai 200444,China;School of Life Sciences,Shanghai University,Shanghai 200444,China)
出处
《药学进展》
CAS
2020年第12期917-923,共7页
Progress in Pharmaceutical Sciences
基金
国家重点研发计划-政府间国际科技创新合作重点专项(No.2018YFE0113500)
国家自然科学基金-重点国际(地区)合作研究项目(No.82020108002)。
关键词
运动
血管稳态
血管重构
生物药物
exercise
vascular homeostasis
vascular remodeling
biological drug
