摘要
采用绿色环保的还原剂聚二烯丙基二甲基氯化铵,制备石墨烯(GR)/聚二烯丙基二甲基氯化铵(PDDA)/铂纳米粒子(PtNPs)复合材料,在此基础上制备了GR/PDDA/PtNPs复合修饰电极,并采用透射电镜、电化学等方法对GR/PDDA/PtNPs进行表征。以pH=8.5的B.R缓冲溶液为支持电解质,采用循环伏安法研究了硝苯地平(Nifedipine,NF)和尼群地平(Nitrendipine,NT)在复合修饰电极上的电化学行为,并优化了电化学测量条件。NF溶液浓度为4.0×10(-7)~1.6×10(-4) mol·L^(-1),NT溶液浓度为1.0×10^(-6)~1.4×10^(-4) mol·L^(-1),它们的还原峰电流与浓度成线性关系,检出限分别为5.0×10^(-8) mol·L^(-1),3.7×10^(-7) mol·L^(-1)。所建立的方法成功应用于血药中NF、NT的测定,获得可靠满意的结果。
Composite material,namely,graphene/polydiallyl dimethyl ammonium chloride/Pt nano-particles(GR/PDDA/PtNPs)was prepared by using PDDA as an environment friendly reducing agent.Based on this,a novel modified electrode,GR/PDDA/PtNPs/GCE was fabricated.This composite modified material,GR/PDDA/PtNPs was characterized byTransmission Electron Microscope(TEM)and electrochemical methods.The electrochemical behavior of Nifedipine(NF)and Nitrendipine(NT)at GR/PDDA/PtNPs/GCE in pH=8.5 britton-robinson(B.R)buffer solution were investigated by using Cyclic voltammetry(CV),and the electrochemical measurement conditions were also optimized.The reduction peak current of NF increases linearly with its concentration within the range of 4.0×10^(-7)~1.6×10^(-4) mol·L^(-1),and the detection limit is 5.0×10^(-8) mol·L^(-1).In the concentration range of 1.0×10^(-6)~1.4×10^(-4) mol·L^(-1),the linear relationship between the reduction peak current of NT and its concentration was obtained.The detection limit is 3.7×10^(-7) mol·L^(-1).The proposed method was employed to determinate NF and NT in sample,and the results are reliable and satisfactory.
作者
王安亭
卫应亮
王璐
王永刚
WANG An-ting;WEI Ying-liang;WANG Lu;WANG Yong-gang(School of Environmental Engineering and Chemistry,Luoyang Institute of Science and Technology,Luoyang 471023,China)
出处
《化学研究与应用》
CAS
CSCD
北大核心
2021年第1期54-61,共8页
Chemical Research and Application
基金
国家自然科学基金项目(21203087)资助
河南省高等学校重点科研项目(17A150038)资助。
