摘要
可变剪接是mRNA经过不同的剪接方式产生不同的mRNA剪接异构体的过程,最终的蛋白产物会表现出不同或者相互拮抗的功能和结构特性。已有大量研究揭示了剪接因子突变与人类多种癌症发生发展密切相关,并通过对不同RNA剪接模式和剪接调控的研究,为肿瘤的治疗提供了大量的候选生物标记物和潜在靶点。最新的mRNA测序技术可检测到大约95%的人类基因与多个外显子进行可变剪接,异常可变剪接可能导致肿瘤的发生。虽然可变剪接在肿瘤中的研究进行的如火如荼,但是其在胃癌发生、发展中的研究目前还较少,该文主要针对可变剪接在胃癌中的研究进展作一综述。
Alternative splicing is the process by which mRNA splices in different ways to produce different mRNA splicing isomers.The final protein products will show different or antagonistic functional and structural characteristics.A large number of studies have revealed that splicing factor mutations are closely related to the occurrence and development of various human cancers.Through the study of different RNA splicing patterns and splicing regulation,a large number of candidate biomarkers and potential targets have been provided for tumor treatment.The latest mRNA sequencing technology can detect that about 95%of human genes have alternative splicing with multiple exons,and abnormal alternative splicing may lead to tumorigenesis.Although the study of alternative splicing in cancer is in full swing,there are few studies on the occurrence and development of gastric cancer.This article reviews the research progress of alternative splicing in gastric cancer.
作者
李洁
王欢
王斌
湛先保
LI Jie;WANG Huan;WANG Bin;ZHAN Xianbao(Department of Oncology,Changhai Hospital,Naval Military Medical University,Shanghai 200433,China)
出处
《中国细胞生物学学报》
CAS
CSCD
2020年第11期2014-2018,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金(批准号:81672892、82072707)资助的课题。
关键词
可变剪接
胃癌
耐药
精准治疗
alternative splicing
gastric cancer
drug resistance
precision medicine
