摘要
目的通过系统评价探讨中国人群2型糖尿病周围神经病变相关危险因素。方法计算机系统检索PubMed、EMbase、中国生物医学文献数据库(CBM)、中国知网(CNKI)、维普中文科技期刊全文数据库(VIP)和万方科技期刊全文数据库(WanFang)中的中国人群2型糖尿病周围神经病变危险因素的相关研究,检索时间限定为2000年1月~2020年2月,同时补充检索纳入文献的参考文献。由两名评价者根据纳入、排除标准进行独立选择文献、提取资料、评价质量后,采用Rev Man 5.3软件进行系统评价,用固定效应模型或随机效应模型合并OR值及95%可信区间(CI)分析各个相关危险因素,采用敏感性分析评估结果的稳定性,用漏斗图评估文献的发表偏倚。结果共纳入文献12篇,总样本量为7886例。纳入分析的危险因素共10个,分别为年龄、糖化血红蛋白、糖尿病病程、空腹血糖、餐后2 h血糖、收缩压、舒张压、总胆固醇、三酰甘油、体重指数。结果显示,年龄、糖尿病病程、糖化血红蛋白、空腹血糖是影响糖尿病周围神经病变发生的危险因素。结论初步确定年龄、糖尿病病程、糖化血红蛋白、空腹血糖是影响糖尿病周围神经病变发生的重要独立危险因素,为临床上糖尿病周围神经病变发生的早期防预提供重要依据。
Objective To investigate the risk factors associated with type 2 diabetic peripheral neuropathy in Chinese population through systematic evaluation.Methods The computer system was used to retrieve the related studies on risk factors for type 2 diabetic peripheral neuropathy in Chinese population in PubMed,EMbase,Chinese biomedical literature database(CBM),China national knowledge infrastructure(CNKI),Weipu Chinese science and technology journal full-text database(VIP)and WanFang databases(WanFang).The retrieval time limit was from January 2000 to February 2020,at the same time,references included in the literature were retrieved complementally.Two reviewers independently selected literatures based on inclusion and exclusion criteria,extracted data,and evaluated the quality using Rev Man 5.3 software for systematic review,using fixed-effect models or random-effect models to combine odds ratio(OR)values and 95%confidence intervals(CI)to analyze various relevant risk factors.Sensitivity analysis was used to evaluate the stability of the results and funnel plot was used to evaluate the publication bias of the literature.Results A total of 12 articles were included,with a total sample size of 7886 cases.There were 10 risk factors included in the analysis,including age,glycosylated hemoglobin,duration of diabetes,fasting blood glucose,2-hour postprandial blood glucose,systolic blood pressure,diastolic blood pressure,cholesterol,triglyceride and body mass index.The results showed that age,course of diabetes,glycosylated hemoglobin,fasting blood glucose were risk facters affecting the occurrence of diabetic peripheral neuropathy.Conclusion It is preliminarily determined that age,course of diabetes,glycosylated hemoglobin and fasting blood glucose are important independent risk factors affecting the occurrence of diabetic peripheral neuropathy.This study provides an important basis for early prevention and treatment of diabetic peripheral neuropathy.
作者
秦明
宋玉玲
张亭
刘长梅
QIN Ming;SONG Yu-ling;ZHANG Ting;LIU Chang-mei(Department of Endocrinology Disease,Binzhou Medical University Hospital,Shandong Province,Binzhou 256600,China)
出处
《中国当代医药》
2021年第1期20-26,共7页
China Modern Medicine
关键词
2型糖尿病
中国人群
周围神经病变
危险因素
系统评价
Type 2 diabetes
Chinese population
Peripheral neuropathy
Risk factors
System evaluation
