摘要
目的研究乳果糖口服溶液联合注射用门冬氨酸鸟氨酸治疗肝性脑病的临床效果及对神经毒性物质、炎症因子水平的影响。方法选取我院收治的94例肝性脑病患者,按照简单随机化法将其分为对照组(47例,乳果糖口服溶液)和观察组(47例,乳果糖口服溶液+注射用门冬氨酸鸟氨酸)。比较两组的神经毒性物质、炎症因子水平、临床疗效及不良反应发生情况。结果治疗后,观察组的β-内啡肽、血氨、hs-CRP、TNF-α、IL-6水平均明显低于对照组(P<0.05)。观察组的治疗总有效率明显高于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论乳果糖口服溶液联合注射用门冬氨酸鸟氨酸治疗肝性脑病的临床效果显著,有助于降低神经毒性物质水平、炎症因子水平。
Objective To study the clinical effect of lactulose oral solution combined with ornithine aspartate for injection in the treatment of hepatic encephalopathy and its influences on neurotoxic substances and inflammatory factors levels.Methods A total of 94 patients with hepatic encephalopathy admitted in our hospital were selected and divided into control group(47 cases,lactulose oral solution)and observation group(47 cases,lactulose oral solution+ornithine aspartate for injection)according to the simple randomization method.The levels of neurotoxic substances,inflammatory factors,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the levels ofβ-endorphin,blood ammonia,hs-CRP,TNF-αand IL-6 in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Lactulose oral solution combined with ornithine aspartate for injection in the treatment of hepatic encephalopathy has a significant clinical effect,which is helpful to reduce neurotoxic substances and inflammatory factors levels.
作者
曹芳
张广文
闫亚平
CAO Fang;ZHANG Guangwen;YAN Yaping(Digestive Emergency Department,the First Affiliated Hospital of Air Force Military Medical University,Xi'an 710013;Shaanxi Normal University,Xi'an 710062,China)
出处
《临床医学研究与实践》
2020年第36期14-16,共3页
Clinical Research and Practice
基金
国家自然科学基金面上项目(No.81571596)。
关键词
肝性脑病
乳果糖
门冬氨酸鸟氨酸
神经毒性物质
炎症因子
hepatic encephalopathy
lactulose
ornithine aspartate
neurotoxic substances
inflammatory factor
