摘要
目的探讨血胆固醇及纤维蛋白原水平对突发性聋(sudden sensorineural hearing loss,SSNHL)发生率和疗效的影响.方法选择2017年1月~2019年5月符合纳入标准的64例SSNHL患者和84名年龄和性别匹配的对照受试者作为研究对象,分析纤维蛋白原、总胆固醇、高密度脂蛋白(high-density lipoprotein,HDL)和低密度脂蛋白(low density lipoprotein,LDL)的血浆浓度对SSNHL发生率和疗效的影响.结果右侧单侧SSNHL占50%,左侧单侧SSNHL占42.2%,双侧同时发病占7.8%,白细胞计数升高占34.4%,C-反应蛋白(C-reactive protein,CRP)水平升高占20.3%.在SSNHL发生率的比较中,诊疗组患者的纤维蛋白原的血浆浓度与对照组相比显著升高[(357±68)mg/dl vs(239±109)mg/dl,P=0.001],诊疗组患者平均HDL血浆浓度与对照组相比有所降低[(1.47±0.41)mmol/L vs(1.80±0.43)mmol/L,P=0.01].在SSNHL疗效的比较中,显效组患者纤维蛋白原的血浆浓度与对照组相比显著升高(P=0.019).结论低HDL胆固醇血浆浓度可能是SSNHL的危险因素之一.纤维蛋白原水平升高和炎症指标的升高可能表明SSNHL的危险性增加.高纤维蛋白原水平与SSNHL预后不良有关,血清纤维蛋白原水平可以作为使用降低血清纤维蛋白原和血液黏度疗法的有用标志物.
Objective To investigate the effects of cholesterol and fibrinogen levels of blood on the incidence and efficacy of sudden sensorineural hearing loss(SSNHL).Methods A total of 64 SSNHL patients and 84 age-and gender-matched control subjects who met the inclusion criteria from January 2017 to May 2019 were selected as the research subjects.The effects of plasma concentrations of fibrinogen,total cholesterol,high-density lipoprotein(HDL)and low density lipoprotein(LDL)on the incidence and efficacy of SSNHL were analyzed.Results Unilateral SSNHL accounted for 50%on the right,42.2%of unilateral SSNHL on the left,simultaneous onset of 7.8%on both sides,an increase in white blood cell count of 34.4%,and an increase in CRP level of 20.3%.In the comparison of the incidenee of SSNHL,the plasma concentration of fibrinogen in the patients in the diagnosis and treatment group was significantly higher than that in the control group[(357±68)mg/dl vs(239±109)mg/dl,P=0.001].The mean HDL plasma concentration of patients was decreased compared with the control group[(1.47±0.41)mmol/L vs(1.80±0.43)mmol/L,P=0.01].In the comparison of the efficacy of SSNHL,the plasma concentration of fibrinogen in the patients in the significant group was significantly higher than that in the control group(P=0.019).Conclusion Low HDL cholesterol plasma concentration may be one of the risk factors for SSNHL.Elevated fibri no gen levels and elevated inflammation in dicators may indicate an increased risk of SSNHL.High fibrinogen levels are associated with poor prognosis for SSNHL.Serum fibrinogen levels can be a useful marker for the use of serum fibrinogen and blood viscosity therapies.
作者
余啸
何哲耘
康骋
应海岳
汪际云
Yu Xiao;He Zheyun;Kang Cheng;Ying Haiyue;Wang Jiyun(Department of Otolaryngology,Hwamei Hospital,University of Chinese Academy of Sciences,Ningbo 315000,China)
出处
《国际耳鼻咽喉头颈外科杂志》
2020年第6期318-322,327,共6页
International Journal of Otolaryngology-Head and Neck Surgery
基金
华美研究基金(2016HMKY42)。
