摘要
目的探讨术前消癌平干预对原发性肝癌(PHC)患者肿瘤标志物、抗肿瘤免疫应答及癌基因表达的影响。方法选取2015年12月至2018年4月于吉安市中心人民医院接受肝癌切除术的98例PHC患者作为研究对象,根据术前处理方案不同分为对照组(无术前特殊干预、n=50)、消癌平组(接受术前消癌平干预、n=48)。比较两组患者入院即刻(T0)、术前1 d(T1)血清肿瘤标志物、外周血抗肿瘤免疫应答指标水平,测定术中肝癌组织中癌基因表达情况。结果 T0时,两组患者血清肿瘤标志物水平、外周血抗肿瘤免疫应答指标水平比较差异无统计学意义(P>0.05)。T1时,消癌平组患者血清甲胎蛋白(AFP)、磷脂酰肌醇蛋白聚糖-3(GPC3)、异常凝血酶原(DCP)水平低于对照组,外周血中CD4+细胞水平高于对照组,CD8+、CD4+CD25+调节性T(Treg)细胞水平低于对照组,差异有统计学意义(P<0.05)。消癌平组患者术中肝癌病灶组织中癌基因Gankyrin、HCCR、FBI-1、Pokemon的m RNA及蛋白表达量显著低于对照组,差异有统计学意义(P<0.05)。结论术前消癌平干预可有效降低PHC恶性程度,可能成为优化治疗结局的可靠手段之一。
Objective To investigate the effect of preoperative Xiao’ai Ping intervention on tumor markers, anti-tumor immune response and oncogene expression in patients with primary liver cancer(PHC). Methods A total of ninety-eight PHC patients admitted to Ji’an People’s Hospital undergoing liver cancer resection from December 2015 to April 2018 were divided into a control group(without preoperative special intervention, n=50) and Xiao’ai Ping group(with preoperative Xiao-Ai-Ping intervention, n=48) according to different preoperative treatment plan.(T1) Serum tumor markers, peripheral blood anti-tumor immune response index levels were compared between two groups at the time of admission(T0) and the day before operation(T1);oncogene expression in liver cancer tissues during operation was determined. Results At the time of T0, there were no significant difference in serum tumor markers and peripheral blood anti-tumor immune response index level between two groups(P>0.05). At the time of T1, the levels of serum alpha-fetoprotein(AFP), glypican-3(GPC3) and abnormal prothrombin(DCP) in the Xiao’aiping group were lower than those in the control group, the levels of CD4+ cells in peripheral blood were higher than those of control group, and CD4+ cell level in peripheral blood were lower than those of control group(P<0.05). The mRNA and protein expression of Gankyrin, HCCR, FBI-1, Pokemon in the liver cancer lesion tissue of patients in the Xiao’ai Ping group were significantly lower than those of control group(P<0.05). Conclusion Preoperative Xiao’ai Ping intervention can effectively reduce the malignant degree of PHC, and may be one of the reliable means to optimize the outcome of treatment.
作者
熊诗峰
杨武
XIONG Shi-Feng;YANG Wu(General Surgery Department of Ji'an People's Hospital,Ji'an 343000,China)
出处
《中国药物经济学》
2020年第10期98-101,共4页
China Journal of Pharmaceutical Economics
