摘要
目的探究白内障术后患者应用表皮生长因子(EGF)联合羟糖甘滴眼液的效果及对患者转化生长因子-β1(TGF-β1)、总抗氧化能力(TAC)的影响。方法回顾性分析2010年12月至2017年12月陕西省友谊医院收治的100例白内障术后患者(100只眼)的临床资料,以EGF治疗的33例(33只眼)作为对照A组,以羟糖甘滴眼液治疗的33例(33只眼)作为对照B组,以EGF联合羟糖甘滴眼液治疗的34例(34只眼)作为联合组。比较三组患者治疗前后的视觉质量[角膜散光、最佳矫正视力(BCVA)、全眼总高阶像差(HOA)]、泪膜功能[泪膜破裂时间(BUT)、基础泪液分泌试验(SIT)、角膜荧光素染色(FL)]、泪液及房水TGF-β1、TAC水平、眼表疾病指数量表(OSDI)、国家眼科学会视功能问卷(NEI-VFQ25)评分,并统计三组患者的不良反应发生情况。结果治疗后,联合组患者的角膜散光、HOA明显低于对照A组、对照B组,BCVA明显高于对照A组、对照B组,且对照A组的角膜散光、HOA明显低于对照B组,BCVA明显高于对照B组,差异均有统计学意义(P<0.05);治疗后,联合组患者的FL评分、SIT明显低于对照A组、对照B组,BUT明显高于对照A组、对照B组,且对照A组的FL评分、SIT明显低于对照B组,BUT明显高于对照B组,差异均有统计学意义(P<0.05);治疗后,联合组患者的房水TGF-β1、泪液TGF-β_1水平明显低于对照A组、对照B组,房水TAC、泪液TAC水平明显高于对照A组、对照B组,且对照A组的房水TGF-β1、泪液TGF-β1水平明显低于对照B组,房水TAC、泪液TAC水平明显高于对照B组,差异均有统计学意义(P<0.05);治疗后,联合组患者的OSDI明显于对照A组、对照B组,NEI-VFQ25评分明显高于对照A组、对照B组,差异均有统计学意义(P<0.05);对照A组、对照B组间的OSDI、NEI-VFQ25评分比较差异均无统计学意义(P>0.05);三组患者的不良反应比较差异无统计学意义(P>0.05)。结论白内障术后应用EGF联合羟糖甘滴眼液能进一步通过缓解局部炎症反应及氧化应激,改善泪膜功能、视觉质量,缓解病情,且不增加不良反应。
Objective To explore the effect of epidermal growth factor(EGF)combined with hydroxyglycoside eye drops on patients after cataract surgery and the influence on transforming growth factor-β1(TGF-β1)and total antioxidant capacity(TAC).Methods The clinical data of 100 postoperative cataract patients(100 eyes),who admitted to Shaanxi Friendship Hospital from December 2010 to December 2017,were retrospectively analyzed.Among them,33 cases(33 eyes)treated with EGF were enrolled as the control group A,33 cases(33 eyes)treated with hydroxyglycoside eye drops were used as the control group B,and 34 cases(34 eyes)treated with EGF combined with hydroxyglycoside eye drops were used as the combined group.The visual quality(corneal astigmatism,best corrected visual acuity[BCVA],total high-order aberration[HOA]),tear film function(tear break-up time[BUT],Schirmer I test[SIT],corneal fluorescein staining[FL]),tear and aqueous humor TGF-β1,TAC levels,ocular surface disease index(OSDI),and 25-item national eye institute visual functioning questionnaire(NEI-VFQ25)scores of patients before and after treatment were compared among the three groups.And the occurrence of adverse reactions in the three groups was counted.Results After treatment,the corneal astigmatism and HOA of the combined group were significantly lower than those of the control group A and the control group B,and the BCVA was significantly higher than that of the control group A and the control group B;the corneal astigmatism and HOA of the control group A were significantly lower than those of the control group B,and the BCVA was significantly higher than that of the control group B;the differences were statistically significant(P<0.05).After treatment,the FL score and SIT of the combined group were significantly lower than those of the control group A and control group B,and the BUT was significantly higher than that of the control group A and control group B;the FL score and SIT of control group A were significantly lower than those of the control group B,and BUT was significantly higher than that of control group B;the differences were statistically significant(P<0.05).After treatment,the levels of aqueous TGF-β1 and tear TGF-β1 of the combined group were significantly lower than those of the control group A and control group B,and the levels of aqueous TAC and tear TAC were significantly higher than those of control group A and control group B.The levels of aqueous TGF-β1 and tear TGF-β1 in the control group A were significantly lower than those in the control group B,and the levels of aqueous TAC and tear TAC were significantly higher than those in the control group B,and the differences were statistically significant(P<0.05).After treatment,the OSDI of the patients in the combined group was significantly higher than that of the control group A and the control group B,and the NEI-VFQ25 score was significantly higher than that of the control group A and the control group B,and the differences were statistically significant(P<0.05).There was no statistically significant difference in OSDI and NEI-VFQ25 scores between the control group A and the control group B(P>0.05);there was no significant difference in the adverse reactions of the three groups of patients(P>0.05).Conclusion The application of EGF combined with hydroxyglycoside eye drops after cataract surgery can further improve the tear film function,visual quality,and alleviate the condition by alleviating local inflammatory response and oxidative stress,without increasing adverse reactions.
作者
张丽
孙文静
ZHANG Li;SUN Wen-jing(Department of Ophthalmology,Shaanxi Friendship Hospital,Xi'an 710068,Shaanxi,CHINA;Department of Ophthalmology,Xi'an Fengcheng Hospital,Xi'an 710016,Shaanxi,CHINA)
出处
《海南医学》
CAS
2020年第23期3088-3092,共5页
Hainan Medical Journal
关键词
白内障
表皮生长因子
羟糖甘滴眼液
转化生长因子-β1
总抗氧化能力
视觉质量
Cataract
Epidermal growth factor(EGF)
Hydroxyglycoside eye drops
Transforming growth factor-β1(TGF-β1)
Total antioxidant capacity(TAC)
Visual quality
