摘要
目的:探讨维生素A棕榈酸酯眼用凝胶对准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)后眼表恢复的影响,评价其疗效及安全性。方法:选取120例240眼接受LASIK手术的患者的左右眼随机分为试验组和对照组,试验组术后应用维生素A棕榈酸酯眼用凝胶,对照组不用,其余治疗相同。测定两组术前,术后1d;1,3mo时泪液分泌量、泪膜破裂时间(break up time,BUT)和角膜知觉,进行统计分析。结果:试验组术后BUT和泪液分泌量恢复快于对照组,差异有统计学意义(P<0.05)。术后1d;1,3mo时试验组角膜知觉和对照组比较差异均无统计学意义(P>0.05),说明维生素A棕榈酸酯眼用凝胶并不是通过促进角膜知觉的恢复而起作用。治疗期间无药物不良反应事件发生。结论:LASIK术后早期使用维生素A棕榈酸酯眼用凝胶有利于眼表重建;但对于角膜知觉的恢复无明显作用。
AIM： To study the effect of vitamin A palmitate eye gel on ocular surface reconstruction after laser in situ keratomileusis（LASlK）, and to evaluate the efficacy and safety. METHODS.. One hundred and twenty patients（240 eyes） performing LASlK were enrolled in this study. The right and left eyes were randomly divided into experimental group and control group. The experimental group were treated with vitamin A palmitate eye gel for 1 month, four times a day after LASlK, and the same as control group in other treatments. The Schirme I test, break- up time （BUT） and corneal sensation were detect at preoperation and the postoperative 1 = day, 1st month, 3rd month in two groups. RESULTS： There were significant difference in BUT and tear secretion quantity between the experimental group and the control group at the postoperative 1st month and 3rd month （ P〈 0.05）, which provided evidence that the postoperative BUT and tear secretion quantity of experimental group recover faster than that of the control group. Comparing with control group, the experimental group had no significant difference in corneal sensation at the postoperative 1st day, 1st month and 3rd month （P〉 0.05）, which revealed that vitamin A palmitate eye gel had no obvious effect on recovery of corneal sensation after LASlK. During the treatment, there was no adverse drug event occurred. CONCLUSION ： Early use of vitamin A palmitate eye gel postoperatively is applicable for ocular surface reconstruction, but has no obvious effect on the regeneration of corneal sensation.
出处
《国际眼科杂志》
CAS
2013年第4期713-715,共3页
International Eye Science
