摘要
妊娠期糖尿病是妊娠期特有的疾病,因未及早地发现血糖异常以及血糖控制欠佳,往往对妊娠结局及新生儿产生不良影响。近年随着对长链非编码RNA(long non-coding RNA,lncRNA)的不断研究,发现lncRNA不仅在肿瘤、肥胖、代谢病和心脑血管疾病等疾病中有影响,同时也在妊娠期糖尿病的发生、发展中起重要作用。LncRNA在患者脐血中有差异表达,其可通过lncRNA-微小核糖核酸(miRNA)轴,或者通过影响下游基因,或者与其他基因相互作用等方式对疾病产生影响,从而出现不良妊娠结局。深入了解妊娠期糖尿病相关的lncRNA的作用机制,进一步探讨妊娠期糖尿病发生发展的分子基础,可能有助于对相关疾病进行及时的预测及治疗。本文对妊娠期糖尿病相关的lncRNA的研究进展作一综述,以期对疾病进行更好地预防及治疗。
Gestational diabetes mellitus(GDM)is a disease unique to pregnancy.Because abnormal blood glucose and poor blood glucose control are not found as early as possible,it often has adverse effects on pregnancy outcomes and neonates.In recent years,with the continuous research of long non-coding RNA(lncRNA),it has been found that lncRNA not only affects tumors,obesity,metabolic diseases,cardiovascular and cerebrovascular diseases,but also plays an important role in the occurrence and development of GDM.LncRNA is differentially expressed in cord blood of patients.It can affect the disease through the lncRNA-miRNA axis,or by affecting downstream genes,or interacting with other genes,resulting in undesirable pregnancy.In-depth understanding of the mechanism of action of lncRNA related to GDM and further exploration of the molecular basis of the development of GDM may help us to timely predict and treat related diseases.This article reviews the research progress of lncRNA related to GDM in order to prevent and treat the disease better.
作者
刘昱彤
陈萱(审校)
LIU Yu-tong;CHEN Xuan(Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150000,China)
出处
《国际妇产科学杂志》
CAS
2020年第6期653-656,共4页
Journal of International Obstetrics and Gynecology
