摘要
肠道菌群与心血管疾病密切相关,肠道菌群相关代谢产物是两者的重要介质。氧化三甲胺(TMAO)是一种常见的肠道代谢产物,在肝脏由三甲胺氧化生成。TMAO在人体水平的升高与肠道菌群失调导致的三甲胺生成增加并大量入血有关。血浆TMAO水平升高在高血压的发生与维持、心肌重构以及动脉粥样硬化斑块的发生发展中起重要作用,有望成为心血管疾病病情评估的重要指标和疾病防治的新靶点。饮食干预、补充特定益生菌等多种手段可有效降低人体血浆TMAO水平,并对心血管系统健康产生影响。
Intestinal flora is closely related to cardiovascular disease,and its metabolites are important mediators between them.Trimethylamine oxide(TMAO)is a common intestinal metabolite which is oxidized by trimethylamine in the liver,and its increased content in human body is related to the large amount of trimethylamine in blood caused by intestinal flora imbalance.The increase of TMAO plays an important role in the occurrence and maintenance of hypertension,myocardial remodeling and the generation and development of atherosclerotic plaque,and is expected to become an important index for the evaluation of cardiovascular disease and a new target for the prevention and treatment.Dietary intervention,supplementation of specific probiotics and other means can effectively reduce the level of human plasma TMAO and have an influence on the health of cardiovascular system.
作者
苍海
李悦
CANG Hai;LI Yue(Department of Cardiovascular Medicine,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《医学综述》
2020年第23期4699-4703,共5页
Medical Recapitulate
关键词
心血管疾病
氧化三甲胺
肠道菌群
Cardiovascular disease
Trimethylamine oxide
Intestinal flora
