摘要
背景:心肌梗死严重威胁人类的健康,现有根治手段非常有限,干细胞生物学和组织工程学的发展为心肌梗死的治疗带来了曙光。目的:文章主要对间充质干细胞的生物学特性、治疗心肌梗死的有效性、移植细胞数量、移植途径、移植时机及作用机制等国内外研究新进展进行综述,为促进间充质干细胞移植治疗心肌梗死的临床转化及应用提供理论参考。方法:以“mesenchymal stem cells,stem cells,biological characteristics,differentiation,proliferation,immunomodulation,homing,paracrine,miocardial infarction,transplantation,RNA methylation”为英文检索词,以“间充质干细胞,干细胞,生物学特性,分化,增殖,免疫调节,归巢,旁分泌,心肌梗死,移植,RNA甲基化”为中文检索词,检索PubMed数据库和CNKI数据库2016至2020年的相关文献,尤其是近3年的文献,剔除重复和不相关的文献,最后纳入53篇文献进行综述。结果与结论:间充质干细胞移植治疗心肌梗死取得了诸多卓有成效的进步,如间充质干细胞向心肌细胞分化、免疫调节、归巢、治疗机制等,但也存在一些争议,如移植治疗的有效性、移植所需的细胞数量、途径及时机等,这些问题制约了间充质干细胞移植治疗的发展。近年来,随着对表观遗传研究的深入,RNA甲基化修饰在间充质干细胞移植治疗心肌梗死中有望实现新的突破。
BACKGROUND:Myocardial infarction is a serious threat to human health,and existing curative treatments are limited.The development of stem cell biology and tissue engineering has shed light on the treatment of myocardial infarction.OBJECTIVE:We intended to review the biological characteristics,effectiveness of treatment,number,route,timing and mechanism of action of transplanted cells,and to provide a theoretical reference to promote translation and application of stem cell transplantation in the treatment of myocardial infarction.METHODS:Key words were“mesenchymal stem cells,stem cells,biological characteristics,differentiation,proliferation,immunomodulation,homing,paracrine,miocardial infarction,transplantation,RNA methylation”in English and Chinese.We mainly searched similar reviews published from 2016 to 2020,especially in recent 3 years,through CNKI and PubMed.The repeated and irrelevant literature was removed.Finally,53 articles were included for review.RESULTS AND CONCLUSION:Successful advances have been made in the prevention and treatment of myocardial infarction,such as the differentiation into myocardium,immune regulation,homing,and therapeutic mechanism.However,controversies still exists,such as the effectiveness of transplantation therapy,the number of cells required for transplantation,as well as the route and timing,which limited the development of stem cell transplantation.Recently,with the deepening of epigenetic research,RNA methylation is expected to achieve a new breakthrough in the treatment of myocardial infarction by stem cell transplantation.
作者
孙维兴
赵永超
赵然尊
Sun Weixing;Zhao Yongchao;Zhao Ranzun(Department of Cardiology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2021年第19期3103-3109,共7页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金项目(NSFC81660049),项目负责人:赵然尊。
关键词
干细胞
间充质干细胞
干细胞移植
心肌梗死
组织工程学
甲基化修饰
综述
stem cells
mesenchymal stem cells
stem cell transplantation
myocardial infarction
tissue engineering
methylation modification
review
