摘要
血管钙化是衰老、动脉粥样硬化、糖尿病、慢性肾病等疾病中的普遍病理现象,并增加心血管疾病的发病率和死亡率。随着血管钙化研究的增多,人们对血管钙化的认知也越来越深入。本文主要从血管平滑肌细胞的成骨型分化、钙化抑制剂的缺失、钙或磷酸盐稳态异常、氧化应激、炎症、细胞凋亡、自噬、基质重塑、miRNA调控等方面介绍血管钙化的分子机制研究的最新进展。本专栏几个课题组分别对活化T细胞核因子c1在糖尿病血管钙化进展中的作用研究、中性粒细胞与淋巴细胞比值与透析患者冠状动脉钙化关系以及霍山石斛对高脂诱导的LDLR基因敲除小鼠动脉粥样硬化和血管钙化的影响进行了较深入的研究。
Vascular calcification is highly prevalent in ageing,atherosclerosis,diabetes and chronic kidney disease,and associated with morbidity and mortality of myocardial infarction.As more investigation input in this field,the better understanding of vascular calcification has been achieved.This review focuses on the molecular mechanism of vascular calcification,including osteogenic transition of vascular smooth muscle cell,defects in calcification inhibitors,disorders of calcium and phosphate homeostasis,oxidative stress,inflammation,apoptosis,autophagy,extracellular matrix remodeling and microRNAs.In this column,several research groups have conducted the in-depth studies on the role of activated T-cell cytoplasmic 1 in the progression of diabetic vascular calcification,the relationship between the ratio of neutrophils to lymphocytes and coronary calcification in dialysis patients,and the effect of Dendrobium huoshanense on atherosclerosis and vascular calcification in LDLR gene knockout mice induced by high-fat food feeding.
作者
梁英权
段亚君
韩际宏
LIANG Yingquan;DUAN Yajun;HAN Jihong(Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes,Hefei University of Technology,Hefei,Anhui 230601,China)
出处
《中国动脉硬化杂志》
CAS
2020年第11期921-929,共9页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金面上项目(81973316)
安徽省重点研究和开发计划项目(201904a07020007)。
关键词
血管钙化
血管平滑肌细胞
钙化抑制剂
氧化应激
炎症
vascular calcification
vascular smooth muscle cell
calcification inhibitor
oxidative stress
inflammation
