摘要
目的探讨功能性垂体腺瘤患者术后早期血清泌乳素(PRL)、生长激素(GH)水平及其意义。方法选取功能性垂体腺瘤患者189例,其中PRL型腺瘤91例,GH型腺瘤98例,均给予全切术治疗,检测手术前后血清PRL、GH水平,随访术后2年复发情况。结果术后2年复发患者25例,总复发率为13.23%,其中PRL型腺瘤复发7例(7.69%),GH型腺瘤复发18例(18.37%)。PRL型腺瘤复发患者术后7 d PRL为(1.22±0.42)nmol/l,明显高于未复发患者(P<0.05);GH型腺瘤复发患者术后7 d GH为(1.14±0.31)nmol/l,明显高于未复发患者(P<0.05)。术后7 d PRL预测PRL型腺瘤患者复发的ROC曲线下面积为0.776,P<0.05,截断值为0.96 nmol/l,灵敏性和特异性分别为85.70%和77.00%;术后7 d GH预测GH型腺瘤患者复发的ROC曲线下面积为0.665,P<0.05,截断值为1.06 nmol/l,灵敏性和特异性分别为55.60%和77.50%。结论术后早期血清PRL、GH水平预测功能性垂体腺瘤患者复发有一定的价值,值得进一步研究。
Objective To explore the significance of serum prolactin(PRL)and growth hormone(GH)levels in patients with functional pituitary adenoma at early stage after operation.Methods 189 patients with functional pituitary adenomas were selected,including 91 PRL adenomas and 98 GH adenomas,all patients were treated with total resection,the serum PRL and GH levels were measured before and after operation,the recurrence rate was followed up for 2 years.Results The total recurrence rate was 13.23%in 25 patients with recurrence in the next 2 years.Of them,7 cases had recurrence of PRL adenoma,the recurrence rate was 7.69%,18 cases had recurrence of GH adenoma,and the recurrence rate was 18.37%;The PRL of patients with PRL-type adenoma recurrence at 7 days after operation was(1.22±0.42)nmol/l,which was significantly higher than that of patients without recurrence(P<0.05);The GH of recurrence of GH-type adenoma patients at 7 days after operation was(1.14±0.31)nmol/L,which was significantly higher than that of non-recurrence patients(P<0.05);The area under the ROC curve for PRL at the 7th day after operationpredicting recurrence of PRL adenoma was 0.776,P<0.05,and the cut-off value was 0.96 nmol/l,the sensitivity and specificity were 85.70%and 77.00%;The area under ROC curve forrGH at the 7th day after operation predicting recurrence of GH-type adenoma was 0.665,P<0.05,and the cut-off value was 1.06 nmol/l,the sensitivity and specificity were 55.60%and 77.50%.Conclusion The serum levels of PRL and GH in early stage after operation can predict the recurrence of functional pituitary adenoma,which is worthy of further study.
作者
代红伟
王霞
李惺
DAI Hongwei;WANG Xia;LI Xing(Zhumadian Central Hospital,Zhumadian,463000)
出处
《实用癌症杂志》
2020年第11期1826-1828,1832,共4页
The Practical Journal of Cancer
关键词
功能性垂体腺瘤
泌乳素
生长激素
复发
预测价值
Functional pituitary adenoma
Prolactin
Growth hormone
Recurrence
Predictive value
