摘要
目的:分析挖掘现代医家治疗郁证验案的用药规律,以期为郁证的临床治疗提供参考。方法:收集整理古今医案云平台(V 1.5)现代医案库、名医医案库中的现代郁证医案,并检索中国期刊全文数据库(CNKI)、中文科技期刊数据库(重庆维普)、中国学术期刊数据库(万方数据)各库建库至2018年10月1日相关期刊文献中的现代郁证医案,提取其中的中药处方数据,利用古今医案云平台(V 1.5)对获取到的处方中药数据进行标准化处理,并利用该平台集成的数据挖掘功能对中药数据进行频次统计、聚类分析、关联分析、复杂网络分析,得到现代医家治疗郁证的常用药物及其属性、分类,常用药对,核心处方。结果:共纳入医案1984个,共计3618诊次,中药处方3089首,共涉及药物1458味,总用药频次39634次。高频药物有柴胡(1546次)、茯苓(1210次)、当归(1167次)、白芍(1109次)、郁金(1091次);药性以温、平为主,药味以苦、辛多见,多归于脾、肺、肝、心经;常用药对有白芍-柴胡、当归-柴胡、柴胡-郁金、当归-白芍、当归-白芍-柴胡等,核心处方以酸枣仁汤、柴胡舒肝散、二陈汤为基础加减。结论:现代医家治疗郁证用药多以疏肝理气、健脾养心为原则,气血兼顾、肝脾心同调、紧扣病机。
Objective To analyze the medication rules of modern physicians on treating depression syndrome,so as to provide reference for clinical treatment of depression syndrome.Methods We collect and sort out the modern medical records of depression syndrome in the cloud platform of ancient and modern medical records(v1.5)and the modern medical records'database of famous doctors,and search CNKI,Chongqing VIP and Wanfang databases for the modern depression medical cases from journals during database establishment time to October 1,2018.We extracted traditional Chinese medicine prescription data in the medical records,and applied the ancient and modern medical records cloud platform(v 1.5)to standardize the acquired TCM data,and integrate data mining function for frequency statistics,cluster analysis,association analysis and complex network analysis to obtain the high frequency of drugs'attributes,classification,and common drug pairs and core prescriptions of modern doctors.Results After screening,a total of 1984 cases were included,3618 cases were diagnosed,and 3089 pieces of data of TCM prescriptions were included.A total of 1458 medicines were involved,and the total frequency of medication was 39634.The high frequency medicines were:Bupleurum chinense(1546 times),Poria cocos(1210 times),Angelica sinensis(1167 times),Paeonia lactiflora(1109 times)and Tulip(1091 times).The commonly used Chinese medicines were mainly warm,flat,bitter and bitter,mostly attributed to the four meridians of spleen,lung,liver and heart.Commonly used medicines were Radix Paeoniae Alba-Bupleurum,Radix Angelicae-Bupleurum,Radix Bupleurum-Tulip,Radix Angelicae-Paeoniae Alba,Radix Angelicae-Paeoniae Alba-Bupleurum,etc.The core prescriptions were Suanzaoren Decoction,Chaihu-Shugan San and Erchen Decoction.Conclusions Modern physicians'treating principles for depression syndrome is soothing liver and regulating qi,invigorating spleen and nourishing heart,emphasizing qi and blood,harmonizing liver,spleen and heart,and linking TCM pathogeneses.
作者
王伟斌
李敬华
于琦
王俊文
张润顺
徐丽丽
王映辉
Wang Weibin;Li Jinghua;Yu Qi;Wang Junwen;Zhang Runshun;Xu Lili;Wang Yinghui(Intelligent Research and Development Center of Traditional Chinese Medicine,Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Smart Traditional Chinese Medicine Research Center,Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;Research Office of Famous and Veteran Chinese Medicine,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100000,China;Literature Resources Research Office,Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China)
出处
《国际中医中药杂志》
2020年第10期1008-1013,共6页
International Journal of Traditional Chinese Medicine
基金
中国中医科学院中央级公益性科研院所"一带一路"合作项目(GH2017-08)
中国中医科学院基本科研业务费自主选题项目(ZZ11-053)。
关键词
郁证
现代医案
古今医案云平台
数据挖掘
用药规律
Depression syndrome
Modern medical records
Ancient and modern medical records cloud platform
Data mining
Medication law
