摘要
目的建立凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(Fbg)、凝血酶时间(TT)的凝固曲线波形分析(CWA)参数CT、|Min1|、|Min2|、|Max2|的参考区间并分析其在凝血因子缺乏患者中的变化。方法通过具有CWA功能的全自动凝血分析仪测定125名表观健康人的标本,建立凝血4项CWA参数CT、|Min1|、|Min2|、|Max2|的参考区间。25例凝血因子缺乏者的标本用于分析凝血4项CWA各参数在疾病中的变化。结果PT的|Min1|(dT/dt)、|Min2|(d2T/dt2)、|Max2|(d2T/dt2)的参考范围分别为3.14±1.22、0.56±0.22和0.50±0.18;APTT的|Min1|(dT/dt)、|Min2|(d2T/dt2)、|Max2|(d2T/dt2)的参考范围分别为4.75±1.71、0.78±0.29和0.65±0.28;Fbg的CT(s)、|Min1|(dT/dt)、|Max2|(d2T/dt2)的参考范围分别为7.01±1.96、1.22±0.51和0.15±0.11;TT的|Min1|(dT/dt)、|Min2|(d2T/dt2)、|Max2|(d2T/dt2)的参考范围分别为0.95±0.32、0.14±0.05和0.07±0.03。凝血因子Ⅴ缺乏患者CWA参数明显减低,|Min2|、|Max2|在凝血因子Ⅶ活性为0.42时明显低于健康人。凝血因子Ⅷ缺乏患者CWA参数随着凝血因子Ⅴ、Ⅷ活性减低明显减低。结论凝血4项CWA参数的参考区间有助于凝血因子缺乏患者的临床判断。
Objective To establish the clot waveform analysis(CWA)reference intervals of prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(Fbg)and thrombin time(TT)parameters CT,|Min1|,|Min2|,|Max2|and observe the changes in patients with coagulation factors deficiency.Methods One hundered and twenty-five cases of apparent healthy person were enrolled to establish the CWA reference intervals of four coagulation parameters and 25 cases with coagulation factors were used to study the changes of CWA patients.Results The CWA reference intervals of PT|Min1|(dT/dt),|Min2|(d2T/dt2),|Max2|(d2T/dt2)are3.14±1.22,0.56±0.22 and 0.50±0.18;The CWA reference intervals of APTT|Min1|(dT/dt),|Min2|(d2T/dt2),|Max2|(d2T/dt2)are 4.75±1.71,0.78±0.29 and 0.65±0.28;The CWA reference intervals of Fbg CT(s),|Min1|(dT/dt),|Max2|(d2T/dt2)are 7.01±1.96,1.22±0.51 and 0.15±0.11;The CWA reference intervals of TT|Min1|(dT/dt),|Min2|(d2T/dt2),|Max2|(d2T/dt2)are 0.95±0.32,0.14±0.05 and 0.07±0.03.These parameters of CWA in factorⅤdeficient patients were significantly reduced,the activity of coagulation factorⅦwas 0.42,|Min2|and|Max2|were significantly lower than that of normal people.The paramenters of CWA in factorⅦdeficient patients were significantly reduce.Conclusion The CWA reference intervals of four CWA parameters helps judgment of coagulation factor deficiency.
作者
孙胜利
陈倩
张建平
吴卫
范连凯
寿玮龄
崔巍
Sun Shengli;Chen Qian;Zhang Jianping;Wu Wei;Fan Liankai;Shou Weiling;Cui Wei(Department of Clinical Laboratory,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Clinical Laboratory,National Cancer Center/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China)
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2020年第10期1008-1013,共6页
Chinese Journal of Laboratory Medicine
