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肠道菌群失调参与2型糖尿病患者认知损害的研究进展 被引量:6

Research progress of intestinal flora imbalance involved in cognitive impairment in type 2 diabetes mellitus
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摘要 部分2型糖尿病(T2DM)患者会发展为轻度认知障碍(MCI),并进一步发展为痴呆。新近研究表明部分T2DM患者发生MCI的同时伴有肠道菌群失调,且脑-肠相互作用参与调控认知功能。提示肠道菌群失调可能是导致MCI的原因之一。但菌群失调与T2DM特征性认知及大脑改变之间的交互作用及神经机制尚不清楚。功能磁共振是研究脑网络的常用技术,运用该技术可探索T2DM早期患者肠道菌群失调和大脑功能网络的特征性改变,探索菌群失调与MCI及大脑改变之间的交互作用机制,为揭示糖尿病MCI特异性神经机制提供影像学证据。
作者 韩文章 李雨婷 胡博 于瀛 王文 Han Wenzhang;Li Yuting;Hu Bo;Yu Ying;Wang Wen
出处 《神经解剖学杂志》 CAS CSCD 北大核心 2020年第5期583-586,共4页 Chinese Journal of Neuroanatomy
基金 国家自然科学基金面上项目(81571656) 陕西省国际合作项目(2015kw-039)。
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