摘要
目的探讨消岩汤联合化疗治疗晚期肺癌患者的临床疗效。方法选取2018年8月至2019年9月间宝鸡市中心医院收治的64例晚期肺癌患者,采用单双数数字标记法随机分为观察组和对照组,每组32例。对照组患者采用化疗治疗,观察组患者在对照组基础上联合消岩汤治疗,比较两组患者治疗前后的体液免疫、肿瘤标志物差异及术后不良反应。结果观察组患者治疗总有效率为84.4%,高于对照组的62.5%,差异有统计学意义(P<0.05)。治疗后,观察组患者IgG、IgM和卡氏评分较治疗前升高,CY21-1和CEA水平较治疗前降低,且观察组患者IgG、IgM和IgA均高于对照组,CY21-1和CEA水平均低于对照组,差异均有统计学意义(均P<0.05)。两组患者治疗后均出现静脉炎、胃肠毒性、骨髓抑制、免疫控制和消化道异常等化疗不良反应,观察组患者总发生率为18.8%(6例),低于对照组的59.4%(19例),两组比较,差异有统计学意义(P<0.05)。结论消岩汤辅助联合化疗治疗晚期肺癌,可有效提高患者的临床疗效和体液免疫功能,抑制肿瘤标志物水平,降低化疗不良反应发生率,值得临床推广使用。
Objective To explore the efficacy of Xiaoyan decoction combined with chemotherapy in the treatment of advanced lung cancer.Methods Sixty-four patients with advanced lung cancer treated at Baoji Central Hospital from August 2018 to September 2019 were selected as the study subjects.They were divided into an observation group and a control group using odd-even number marking method with 32 patients in each group.The observation group was given Xiaoyan decoction combined with chemotherapy and the control group was given chemotherapy.Humoral immunity and tumor markers adverse reactions after operation were compared between the two groups.Results The overall efficacy rate was 84.4%in the observation group than 62.5%of the control group(P<0.05).The scores of Ig G,Ig M and Karnofsky performance status score increased and the levels of CY21-1 and CEA decreased in the observation group after the treatment than those before the treatment and the scores of Ig G,Ig M and Karnofsky performance status were higher in the observation group than in the control group and the levels of CY21-1 and CEA were significantly lower in the observation group than in the control group(all P<0.05).Complications including phlebitis,gastrointestinal toxicity,myelosuppression,immune control and digestive tract abnormalities occurred in both groups.The incidence of complications was 18.8%(6 patients)in the observation group and 59.4%(19 patients)in the control group(P<0.05).Conclusion Xiaoyan decoction combined with chemotherapy for advanced lung cancer can effectively improve the clinical efficacy and humoral immune function,inhibit the level of tumor markers and reduce the incidence of adverse reactions associated with postoperative chemotherapy,which is worthy of popularization in clinical practice.
作者
张斌
刘小凤
李康
ZHANG Bin;LIU Xiao-feng;LI Kang(Department of Oncology,Baoji Central Hospital,Baoji 721000,China)
出处
《中国肿瘤临床与康复》
2020年第9期1089-1092,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
消岩汤
晚期肺肿瘤
药物疗法
体液免疫
不良反应
Xiaoyan decoction
Advanced lung neoplasms
Drug therapy
Humoral immunity
Adverse reactions
