摘要
目的研究肠内营养对乳腺癌术后化疗患者肠道菌群、生活质量、营养指标水平的影响。方法选取2012年7月至2018年1月于我院进行乳腺癌术后化疗的91例女性乳腺癌患者为研究对象,根据是否进行肠内营养将患者分为肠内营养组和对照组,观察化疗前后2组患者肠道菌群、生活质量、营养指标水平的变化及不良反应发生情况。结果治疗前2组患者肠道菌群、生活质量、营养指标水平差异无统计学意义(均P>0.05)。治疗后,肠内营养组患者肠道双歧杆菌数量为(6.7±0.5)lg CFU/g、乳杆菌数量为(8.5±0.4)lg CFU/g,均显著高于治疗前,同时显著高于对照组(均P<0.05)。治疗后肠内营养组患者出现反酸、腹胀、便秘等胃肠道不良反应的比例与对照组比较差异无统计学意义(均P>0.05)。治疗后两组患者总体健康、认知功能、情绪功能、角色功能、社会功能、活力、躯体疼痛、躯体功能评分显著高于治疗前(均P<0.05),且肠内营养组患者生活质量各指标的评分显著高于对照组(均P<0.05)。治疗后肠内营养组患者血清总蛋白(TB)、血清清蛋白(ALB)、血清前清蛋白(PA)、转铁蛋白(TF)水平均显著高于对照组(均P<0.05)。结论肠内营养可预防乳腺癌术后化疗患者肠道菌群的紊乱及营养不良的发生,安全有效,有助于提高乳腺癌患者的生活质量。
Objective To study the effect of enteral nutrition on gut microbiota,quality of life and nutritional indexes of breast cancer patients receiving postoperative chemotherapy.Methods A total of 91 female breast cancer patients who underwent postoperative chemotherapy in our hospital from July 2012 to January 2018 were enrolled and divided into enteral nutrition group or control group.The changes of gut microbiota,quality of life,nutritional indexes and adverse reactions in the two groups before and after chemotherapy were observed.Results There were no significant differences in gut microbiota,quality of life and nutritional indexes between the two groups before treatment(all P>0.05).After treatment,Bifidobacterium and Lactobacillus in the enteral nutrition group(lg CFU/g,6.7±0.5,8.5±0.4)were significantly higher and significantly higher than those in the control group(all P<0.05).There were no significant differences in acid regurgitation,abdominal distension,constipation and other adverse gastrointestinal reactions between two groups(all P<0.05).The scores of overall health,cognitive function,emotional function,role function,social function,vitality,physical pain and physical function in the two groups after treatment were significantly higher than those before treatment(all P<0.05).The scores of quality of life in the enteral nutrition group were significantly higher than those in the control group(all P<0.05).The levels of TB,ALB,PA and TF in the enteral nutrition group were significantly higher than those in the control group(all P<0.05).Conclusion Enteral nutrition can prevent the disorder of gut microbiota and the occurrence of malnutrition in breast cancer patients receiving postoperative chemotherapy.It is safe and effective and is conducive to improving the quality of life of breast cancer patients.
作者
万毅
姚永强
解继平
谢丹
张岷
巴金玲
WAN Yi;YAO Yongqiang;XIE Jiping;XIE Dan;ZHANG Min;BA Jinling(Department of Breast and Thyroid Surgery,Affiliated Zhongshan Hospital of Dalian University,Dalian,Liaoning 110001,China;不详)
出处
《中国微生态学杂志》
CAS
CSCD
2020年第10期1157-1161,共5页
Chinese Journal of Microecology
基金
湖北陈孝平科技发展基金会肿瘤防治研究槐耳专项基金(CXPJJH11800004-010)。
关键词
肠内营养
肠道菌群
生活质量
乳腺癌
Enteral nutrition
Gut microbiota
Quality of life
Breast cancer
