摘要
目的探讨苏红汤外用联合艾瑞昔布片口服治疗膝关节骨性关节炎的临床疗效。方法将纳入的64例膝关节骨性关节炎患者按随机数字表随机分为苏红汤外用联合艾瑞昔布片口服组(治疗组,n=32例)和单纯艾瑞昔布片口服组(对照组,n=32)。观察2组患者治疗前后的疼痛评分(VAS评分)、膝关节功能评分(WOMAC评分)、疗效情况以及不良反应等,并于治疗结束后3个月以电话或者门诊复诊形式进行疗效回访,观察2组患者的短中期疗效。结果治疗组和对照组总有效率分别为93.33%和83.33%,2组间疗效比较差异有统计学意义,P <0.05。治疗组经过治疗后VAS评分和WOMAC评分与对照组相比,差异均有统计学意义(P <0.05)。治疗结束3个月后随访,治疗组的VAS评分和WOMAC评分与对照组相比,差异均有统计学意义(P <0.05)。且2组患者在治疗后和随访时的VAS评分和WOMAC评分较治疗前降低,差异有统计学意义(P <0.05)。2组在治疗和随访期间均未见明显不良反应。结论苏红汤外用联合艾瑞昔布片口服治疗膝关节骨性关节炎的临床疗效优于单纯口服艾瑞昔布片组,且其有着较好的短中期效果,是一种经济、安全、有效的治疗手段。
Objective To investigate the clinical effect of Suhong decoction combined with imrecoxib for the treatment of knee osteoarthritis. Methods According to the random number table, 64 patients with knee osteoarthritis were randomly divided into Suhong decoction combined with imrecoxib group(treatment group, n=32 cases) and imrecoxib group(control group, n=32 cases). VAS score, WOMAC score, efficacy and adverse reactions were observed before and after treatment in patients of the two groups, and the short-term efficacy was also observed in patients of the two groups by telephone or outpatient visit 3 months after treatment. Results The total effective rate of the treatment group and the control group was 93.33% and 83.33% respectively, and the difference between the two groups was statistically significant(P<0.05). The difference of the VAS score and WOMAC score was statistically significant between the control group and the treatment group(P<0.05). Three months after the end of treatment, The difference of the VAS score and WOMAC score was still statistically significant between the two groups(P<0.05). VAS score and WOMAC score of patients in both groups decreased after treatment and during follow-up with statistically significant difference(P<0.05). No significant adverse reactions occurred between the two groups. Conclusion Suhong decoction combined with imrecoxib therapy for the treatment of knee osteoarthritis is superior to the group of imrecoxib therapy, and its short-term and medium-term effect is better. In general, it is a safe, economical and effective treatment method.
作者
黄法森
马玉峰
吴俊德
张伟
谢坤铭
梁欢
陶经纬
朱涵杰
陈兆军
HUANG Fasen;MA Yufeng;WU Junde;ZHANG Wei;XIE Kunming;LIANG Huan;TAO Jingwei;ZHU Hanjie;CHEN Zhaojun(The Third Affiliated Hospital of Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《吉林中医药》
2020年第10期1327-1330,共4页
Jilin Journal of Chinese Medicine
基金
北京市中医管理局(201803190106)。
