摘要
目的观察夏仙逍遥饮对围绝经期失眠症患者的糖代谢和胰岛素抵抗的影响。方法将60例肝郁化火型围绝经期失眠症患者随机分为对照组和观察组,每组各30例。对照组采用克龄蒙联合右佐匹克隆治疗,观察组采用中药夏仙逍遥饮。比较2组患者治疗前后的空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1C)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)和肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)等。结果治疗后,2组患者FPG、2hPG、HbA1C水平均明显降低(P<0.05),且治疗组降低程度优于对照组(P<0.05)。2组患者FINS和HOMA-IR水平明显降低(P<0.05),且治疗组降低程度优于对照组(P<0.05)。2组患者TNF-α和IL-6水平明显降低(P<0.05),且治疗组降低程度优于对照组(P<0.05)。结论夏仙逍遥饮能够能明显降低围绝经期失眠症患者的FPG、2hPG和HbA1C水平,还能显著抑制患者FINS和HOMA-IR水平,并能显著恢复异常升高的TNF-α和IL-6,恢复失衡的糖代谢、改善胰岛素抵抗和抑制因子的作用,其具体作用机制值得进一步探究。
Objective To observe the effects of Xiaxian Xiaoyao drink on glucose metabolism and insulin resistance in patients with peri-menopausal insomnia.Methods 60 patients with peri-menopausal insomnia were randomly divided into control group and observation group,with 30 cases in each group.The control group was treated with Climen combined with Eszopiclone,and the observation group was treated with Xiaxian Xiaoyao drink.The FPG,2hPG,HbA1C,FINS,HOMA-IR,TNF-αand IL-6 of the two groups was compared.Results After treatment,the levels of FPG,2hPG and HbA1C in the two groups were both significantly decreased(P<0.05).And the levels of the FPG,2hPG and HbA1C of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The levels of FINS and HOMA-IR was significantly decreased both in the control group and the observation group after treatment,and the difference was statistically significant(P<0.05).And the levels of the FINS and HOMA-IR of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).The levels of TNF-αand IL-6 was significantly decreased both in the control group and the observation group after treatment,and the difference was statistically significant(P<0.05).And the levels of the TNF-αand IL-6 of the observation group was better than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Xiaxian Xiaoyao drink can significantly reduce the levels of FPG,2hPG and HbA1C in patients with peri-menopausal insomnia,also significantly inhibit the peri-menopausal insomnia patients’FINS and HOMA-IR levels,significantly restore the levels of the TNF-αand IL-6.Xiaxian Xiaoyao drink can Restore the unbalanced glucose metabolism,improve the insulin resistance and inhibit the inflammatory factors of the peri-menopausal insomnia patients.Its specific mechanism of action deserves further exploration.
作者
陈燕芬
卢军
叶坚旭
方米泥
张伯涛
林银川
林云奇
CHEN Yanfen;LU Jun;YE Jianxu;FANG Mini;ZHANG Botao;LIN Yinchuan;LIN Yunqi(Department of Internal Medicine,Puning Hospital of Traditional Chinese Medicine,Guangdong Province,Puning 515300,China)
出处
《中国中医药现代远程教育》
2020年第16期64-66,共3页
Chinese Medicine Modern Distance Education of China
基金
广东省教育厅临床教学基地教学改革研究项目【No.2018JD092】
广东省中医药局面上项目【No.20201413】
广东省揭阳市科技创新项目【No.2018wsyl046】。
关键词
围绝经期
睡眠障碍
胰岛素抵抗
糖代谢
脏躁
peri-menopausal period
sleep disorder
insulin resistance
glucose metabolism
hysteria
