摘要
目的:研究男性不育症患者生殖道支原体感染情况及药敏分析。方法:选择2018年6月-2019年7月笔者所在医院收治的218例不育症患者作为研究组,包括原发性不育症110例(原发组)和继发性不育症108例(继发组);将同期于笔者所在医院进行健康体检的205例健康男性作为对照组。对两组支原体感染率进行统计,并对比药敏结果。结果:研究组支原体感染145例(66.51%),其中解脲支原体(Uu)113例(51.83%),人型支原体(Mh)6例(2.75%),混合感染(Uu+Mh)26例(11.93%),均高于对照组,差异均有统计学意义(P<0.05)。原发组与继发组Uu、Mh、Uu+Mh感染率比较,差异均无统计学意义(P>0.05)。药敏方面,Uu对甲砜霉素、克林霉素、罗红霉素耐药性较高,对美满霉素、交沙霉素、强力霉素敏感性较高;Mh对红霉素、甲砜霉素、罗红霉素耐药性较高,对强力霉素、交沙霉素、美满霉素、阿奇霉素、克拉霉素、左氧氟沙星、加替沙星敏感性较高;Uu+Mh对甲砜霉素、阿奇霉素、克林霉素耐药性较高,对司帕沙星敏感性较高。结论:在男性不育症患者中,支原体感染率较高,可能是引起男性不育的重要因素之一。临床应针对患者的实际情况选择相应的抗生素以改善病情。
Objective:To study mycoplasma infection in genital tract in male infertility patients and analysis of drug sensitivity.Method:A total of 218 patients with infertility admitted to our hospital from June 2018 to July 2019 were selected as the study group,including 110 cases of primary infertility(the primary group)and 108 cases of secondary infertility(the secondary group).At the same time,205 healthy men who had routine physical examination in our hospital were selected as the control group.The infection rate of mycoplasma of the two groups was counted,and then the drug sensitivity results were compared.Result:A total of 145 cases(66.51%)had mycoplasma infection in the study group,including 113 cases(51.83%)of Ureaplasma urealyticum(Uu),6 cases(2.75%)of Mycoplasma hominis(MH),26 cases(11.93%)of mixed infection(Uu+MH),which were higher than those of the control group,and the differences were statistically significant(P<0.05).The infection rates of Uu,Mh and Uu+Mh in the primary group and the secondary groups were compared,and the differences were not statistically significant(P>0.05).In terms of drug sensitivity,Uu showed higher drug resistance to Thiamphenicol,Clindamycin,Roxithromycin,and higher sensitivity to Minocycline,Josamycin and Doxycycline.Mh showed higher drug resistance to Erythromycin,Thiamphenicol and Roxithromycin,and higher sensitivity to Doxycycline,Josamycin,Minocycline,Azithromycin,Clarithromycin,Levofloxacin and Gatifloxacin.Uu+Mh showed higher drug resistance to Thiamphenicol,Azithromycin and Clindamycin,and higher sensitivity to Sparfloxacin.Conclusion:In male infertility patients,mycoplasma infection rate is high,may be one of the important factors causing male infertility.In order to improve the condition,antibiotics should be selected according to the actual situation of patients.
作者
方燕华
吕福通
刘凤琼
FANG Yanhua;LYU Futong;LIU Fengqiong(Guangxi Zhuang Autonomous Region Reproductive Hospital,Nanning 530021,China;不详)
出处
《中外医学研究》
2020年第22期81-83,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
男性不育症
生殖道支原体感染
药敏
Male infertility
Mycoplasma infection in genital tract
Drug sensitivity
