摘要
多药耐药性是目前传染病治疗中的一个日益严重的问题,广谱抗生素的广泛使用已经使许多人类细菌病原体产生了耐药性.耐药性的增强使细菌感染的发病率、死亡率和疾病治疗费用显著增加.因此,开发、修饰或寻找对多药耐药菌有杀菌作用的新型化合物迫在眉睫.根据文献调研发现,银纳米粒子具有优异的杀菌活性,影响细菌生物膜的生长和成熟,数百年来一直被用来预防和控制各种感染性疾病,为解决致病菌对抗生素耐药性问题提供了新思路.银纳米粒子与抗生素的有效结合会对多药耐药菌产生较强的杀菌效果,有希望成为传统抗菌材料的替代品.本文综述了银纳米粒子的抗菌机制和抗生物膜形成的活性,以及解决细菌多药耐药问题的各种方案,特别是银纳米粒子与抗生素的联合使用.
Multidrug resistance is an increasingly serious problem in the treatment of infectious diseases.The widespread use of broad-spectrum antibiotics has made many human bacterial pathogens resistant.Increased drug resistance significantly increases the morbidity,mortality and disease treatment costs of bacterial infections.Therefore,it is urgent to develop,modify or find new compounds that have bactericidal effect on multidrug resistant bacteria.According to the literature research,it is found that silver nanoparticles have excellent bactericidal activity,affecting the growth and maturation of bacterial biofilms,and have been used for the prevention and control of various infectious diseases for hundreds of years,providing a new idea for solving the problem of antibiotic resistance of pathogenic bacteria.It has been proved that the effective combination of silver nanoparticles and antibiotics will produce an enhanced bactericidal effect on multi-drug resistant bacteria,which is expected to be a substitute for traditional antibacterial materials.The purpose of this review is to summarize the antibacterial mechanism and anti-biofilm activity of silver nanoparticles,to discuss the toxicity of silver nanoparticles,and to design new solutions to the current multi-drug resistance problem of bacteria,especially the combination of silver nanoparticles and antibiotics.
作者
刘静
薛岚
郭晓媛
王春章
李明雪
LIU Jing;XUE Lan;GUO Xiaoyuan;WANG Chunzhang;LI Mingxue(College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475004,Henan,China)
出处
《化学研究》
CAS
2020年第3期252-262,共11页
Chemical Research
基金
国家自然科学基金面上资助项目(21671055).
关键词
纳米银
抗菌活性
抗生物膜
Ag NPs
antibacterial activity
antibiofilm
