摘要
目的 探讨儿童青少年抗精神病药物超说明书用药情况,为合理用药提供参考依据.方法 收集2018年7月~2019年8月期间儿少科使用抗精神病药物的患者资料,利用回顾性分析方法,将患者的姓名、性别、年龄、诊断、抗精神病药物名称、用法用量、给药途径等资料汇总进行统计分析,以药品说明书为依据判定是否存在超说明书用药.结果 共收集388例患者资料,男204名,女184名,平均年龄为(13.89±2.55)岁.使用抗精神病药的医嘱有2234条,超说明书用药医嘱有1560条,超说明书总发生率为69.8%.超适应证发生率占超说明书用药情况的36.0%,超用药人群发生率占47.1%,超给药途径发生率占16.8%.结论 该院儿童青少年抗精神病药物使用普遍存在超说明书用药现象,应进一步规范超说明书用药行为,从而避免不良反应的发生,促进安全合理用药.
Objective To explore the off-label use of antipsychotic drugs in children and adolescents of our hospital,and provide reference for rational drug use.Methods Collect data on patients using antipsychotic drugs in Child and Adolescent Psychiatry from July 2018 to August 2019.We used retrospective analysis to collect the patient's name,gender,age,diagnosis,antipsychotic drug,dosage,administration route for statistical analysis.We judged the off-label use of antipsychotic drug according to the drug instructions.Results A total of 388 patients were collected,including 204 males and 184 females,with an average age of(13.89±2.55)years.There were 2234 medical orders of antipsychotic drugs and 1560 medical orders were off-label use with a total incidence of 69.8%.The incidence of over-indication was 36.0%,the incidence of over-population was 47.1%and the incidence of over-administration route was 16.8%.Conclusion Off-label use of antipsychotic drugs in children and adolescents of our hospital was a common phenomenon.Off-label drug use behaviors should be Standardized to avoid adverse reactions and promote safe and rational drug use.
作者
朱静
ZHU Jing(Xuzhou Oriental People’s Hospital,Xuzhou,Jiangsu 221004,China.)
出处
《中国处方药》
2020年第8期45-47,共3页
Journal of China Prescription Drug
