摘要
随着我国医药事业的不断发展,中药在治疗疾病和养生保健方面得到广泛应用的同时,其毒副作用也逐渐被人们所重视。肝脏作为药物代谢的重要场所,同时也是毒性反映的主要靶器官,关于中药引起肝损伤的临床报道屡见不鲜,中药肝毒性问题已成为了限制中医药国际化的一个重要原因。代谢组学作为一门研究生物体系代谢途径的新兴学科,在中药肝毒性研究中表现出整体性和系统性,为寻找中药肝损伤的早期生物标志物、探讨中药的肝毒性机制提供了新的技术方法。该文通过对代谢组学在中药肝毒性研究中的方法,以及基于代谢组学的肝毒性中药单体、提取物和肝毒性中药减毒作用的研究进展进行综述,旨在为中药肝毒性的进一步研究提供参考。
With the continuous development of Chinese medicine,traditional Chinese medicine(TCM)has been widely used in the treatment of diseases and health care.At the same time,the toxic and side effects of TCM have been gradually concerned.The liver,as an important place for drug metabolism,is a major target organ for drug toxicity.Clinical reports on liver injury caused by TCM are common,and the problem of liver toxicity of TCM has become an important reason to limit the internationalization of TCM.Metabono-mics is a newly booming subject to study the metabolic pathway of biological system.It shows integrity and systematicness in the study of hepatotoxicity of TCM,which provides a new technical method for finding the early biomarkers of liver injury of TCM and exploring the mechanism of hepatotoxicity of TCM.In this paper,the methods of metabonomics in the study of hepatotoxicity of TCM,as well as the research progress of hepatotoxicity monomer,extract and attenuation of hepatotoxic TCM based on metabonomics were reviewed in order to provide reference for the further study of hepatotoxicity of TCM.
作者
胡聪
黎红维
吴琳静
熊印华
HU Cong;LI Hong-wei;WU Lin-jing;XIONG Yin-hua(School of Pharmacy,Jiangxi Science and Technology Normal University,Nanchang 330013,China;Jiangxi Provincial Key Laboratory of Drag Design and Evaluation,Nanchang 330013,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2020年第11期2493-2501,共9页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(81660692)
江西省教育厅科学技术研究项目(GJJ170683)
江西省药物分子设计与评价重点实验室项目(20171BCD40015)。
关键词
中药
肝毒性
代谢组学
traditional Chinese medicine
hepatotoxicity
metabonomics
