摘要
目的应用实时剪切波弹性成像(shear-wave elastography,SWE)探讨乳腺浸润性导管癌剪切波弹性模量最大值(Emax)与乳腺癌内分泌免疫受体雌激素受体(estrogen receptor,ER)、孕激素受体(progesterone receptor,PR)的相关性。方法选择经病理证实的乳腺浸润性导管癌患者71例(共76个病灶),术前均行常规超声及SWE检测,记录其弹性模量最大值(Emax);术后记录其临床病理及内分泌免疫受体ER、PR表达结果,运用t检验及线性回归分析判断ER、PR表达与Emax间的相关性,并行ER表达阴性危险因素的相关分析。结果对乳腺浸润性导管癌(共76个病灶)Emax值与内分泌免疫受体ER、PR进行统计学分析,ER表达阳性组Emax值低于ER表达阴性组,其差异具有统计学意义(P=0.046),PR表达阳性组Emax值低于PR表达阴性组,其差异具有统计学意义(P=0.041),应用线性回归分析,ER表达与Emax具有负相关性(P<0.001,β=-0.91),PR表达与Emax不具有相关性(P>0.05),运用Logistic回归分析传统超声中典型恶性征象边缘(光滑、毛刺、分叶)、微钙化、纵横比及剪切波弹性成像Emax值,统计结果分析显示Emax值增高是ER表达阴性的独立危险因素(P=0.038)。结论乳腺浸润性导管癌Emax值与内分泌免疫受体ER表达具有负相关性,通过对Emax值分析可以对浸润性导管癌患者内分泌免疫受体ER表达进行预判,为临床运用内分泌治疗乳腺浸润性导管癌提供新的影像学依据。
Objective To investigate the shear wave elastic modulus maximum(Emax)of breast invasive ductal carcinoma and the estrogen receptor(ER)of breast cancer using real-time shear-wave elastography(SWE),the correlation of progesterone receptor(PR).Methods Seventy-one patients with pathologically proven breast invasive ductal carcinoma(76 lesions)were selected.All patients underwent routine ultrasound and SWE before operation.The maximum elastic modulus(Emax)was recorded.The clinical pathology was recorded after operation.Endostatic immunoreceptor ER,PR expression results,using t test and linear regression analysis to determine the correlation between ER,PR expression and Emax,and the correlation analysis of negative ER expression risk factors.Results Emax values and endocrine immunoreceptors ER and PR were statistically analyzed in breast invasive ductal carcinoma(76 lesions).The Emax value of ER expression positive group was lower than that of ER expression negative group.The difference was statistically significant(P=0.046),the Emax value of PR positive group was lower than that of the PR negative group(P=0.041).Using linear regression analysis,ER expression was negatively correlated with Emax(P<0.001,β=-0.91),PR expression was not correlated with Emax(P>0.05).Logistic regression was used to analyze the Emax values of typical malignant signs(smooth,burr,leaf),microcalcification,aspect ratio and shear wave elastography in traditional ultrasound.Statistical analysis showed that elevated Emax was an independent risk factor for negative ER expression(P=0.038).Conclusion The Emax value of invasive ductal carcinoma of the breast is negatively correlated with the expression of ER in endocrine immunoreceptors.The expression of Emax can be used to predict the expression of endocrine immunoreceptor ER in patients with invasive ductal carcinoma.Sexual ductal carcinoma provides a new imaging basis.
作者
刘逸群
吴迪
刘玉洁
李晓超
王怡
LIU Yi-qun;WU Di;LIU Yu-jie;无(Department of Pathology of Qinhuangdao First Hospital Qinhuangdao First Hospital,Qinhuangdao 066000,China;Department of Ultrasonography Qinhuangdao First Hospital)
出处
《中国实验诊断学》
2020年第7期1068-1071,共4页
Chinese Journal of Laboratory Diagnosis
基金
秦皇岛市重点研发计划科技支撑项目(201805A054)。
关键词
剪切波弹性成像
乳腺浸润性导管癌
雌激素受体
孕激素受体
shear wave elastography
invasive ductal carcinoma of the breast
estrogen receptor
progesterone receptor
