摘要
基底细胞癌是最常见的皮肤恶性肿瘤。随着基因测序技术的进步,已发现多个基因参与基底细胞癌的发病机制。其中,PTCH1、SMO、GLI、SUFU的突变导致Hedgehog(HH)通路的异常激活、TP53基因突变与基底细胞癌关系最密切。此外,一些新基因及通路也参与基底细胞癌的形成及发展,包括Hippo-YAP通路、MYCN/FBXW7基因、TERT基因、DPH3-OXNAD1基因等。本文回顾了近年来基底细胞癌研究的主要分子机制。
Basal cell carcinoma(BCC)is the most common human malignant cancer.With the improvement of gene-sequencing technology,more complex cancer-associated genes has been found to involved in BCC.The abnormal activation of Hedgehog pathway which caused by mutation of PTCH1,SMO,GLI,SUFU together with TP53 gene mutation have the closest relationship with BCC.Besides,some new genes and pathways have been found to form and drive BCC,including Hippo-YAP pathway,MYCN/FBXW7 gene,TERT gene,DPH3-OXNAD1 gene.This article reviews the genetic mechanism of basal cell carcinoma in recent years.
作者
杨仙鸿
姜祎群
孙建方
YANG Xianhong;JIANG Yiqun;SUN Jianfang(Department of Pathology,Hospital of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College,Nanjing 210042,China)
出处
《中国皮肤性病学杂志》
CAS
CSCD
北大核心
2020年第8期955-958,共4页
The Chinese Journal of Dermatovenereology
基金
中国医学科学院医学与健康科技创新工程重大协同创新项目(CIFMS-2017-I2M-1-017)。
