摘要
近年来,随着工业化进程的加快,空气污染问题日益严重。国内外大量研究表明,空气中的污染物尤其是细颗粒物(fine particulate matter,PM2.5)与人体疾病的发展密切相关,对人类呼吸系统、心血管系统、中枢神经系统、生殖系统等有不良影响。研究表明:PM2.5主要通过诱导细胞产生氧化应激和炎症反应、疾病相关基因多态性与DNA甲基化、介导相关基因表达调控、诱发信号通路改变等途径来致病。本文从PM2.5的组分、来源、对人体健康的危害及相关机制研究的角度进行了综述。
Recently,the problem of air pollution is worsening along with the process of industrialization.Researches from home and abroad have shown that air pollution,especially fine particles(fine particulate matter,PM2.5),is closely associated with the development of diseases,and has adverse effects on respiratory system,cardiovascular system,central nervous system and reproductive system. Studies have shown that the mechanism of diseases caused by PM2.5 is mainly including cell oxidative stress and inflammatory response induced by particulate matter,disease-related gene polymorphism and DNA methylation,mediating the regulation of related gene expression and inducing the change of signal pathways.In this review,the components,sources,and the pathogenic mechanism of PM2.5 are summarized.
作者
段肖肖(综述)
刘思秀(审校)
DUAN Xiao-xiao;LIU Si-xiu(Department of Environmental Science and Engineering,Fudan University,Shanghai 200438,China;Shanghai Key Laboratory of Atmospheric Particle Pollution Prevention,Fudan University,Shanghai 200438,China)
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2020年第4期605-614,共10页
Fudan University Journal of Medical Sciences
基金
国家自然科学基金(21577020,21876031)。
