摘要
目的:观察分析熊去氧胆酸辅助治疗婴儿胆汁淤积症的效果。方法:选取2018年8月-2019年7月在笔者所在医院接受治疗的70例胆汁淤积症患儿作为研究对象,采取随机分组的方式将其分为对照组(35例)与研究组(35例),对照组采取常规保肝药治疗,研究组在对照组基础上采取熊去氧胆酸辅助治疗,分析两组患儿治疗前后的肝生化指标变化、治疗效果及不良反应发生率。结果:研究组治疗后,治疗有效率为91.43%,明显高于对照组的80.00%,差异有统计学意义(P<0.05);两组治疗前DBIL、TBIL、ALT、AST等指标比较,差异无统计学意义(P>0.05),治疗后两组DBIL、TBIL、ALT、AST等指标明显下降,研究组下降程度明显优于对照组(P<0.05);两组均未出现严重不良反应,研究组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论:婴儿胆汁淤积症采取熊去氧胆酸辅助治疗能有效提高治疗效果,促进肝功能恢复,安全又可靠,值得临床推广。
Objective:To observe the therapeutic effect of Ursodeoxycholic Acid on infant of cholestasis.Method:A total of 70 infant with cholestasis were treated in our hospital from August 2018 to July 2019 who were selected as the study objects.They were randomly divided into the control group(35 cases)and the study group(35 cases).The control group was treated with routine liver protection drugs,and the study group was treated with Ursodeoxycholic Acid on the basis of the control group.The changes of liver biochemistry of the two groups before and after treatment,therapeutic effect and incidence of adverse reactions were analyzed.Result:After treatment,the effective rate of 91.43%in the study group,was significantly higher than 80.00%of the control group,the differences was statistically significant(P<0.05).There was no significant difference in DBIL,TBIL,ALT,AST and other indicators between the two groups before treatment(P>0.05);after treatment,DBIL,TBIL,ALT,AST and other indicators in the study group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).No serious adverse reaction occurred in the two groups,and the incidence of adverse reactions in the study group compared with that in the control group,there was no significant difference(P>0.05).Conclusion:Ursodeoxycholic Acid can effectively improve the therapeutic effect and promote the recovery of liver function in infant cholestasis,which is safe and reliable and worthy of clinical promotion.
作者
胡海燕
HU Haiyan(Quanzhou Children’s Hospital,Quanzhou 362017,China)
出处
《中外医学研究》
2020年第21期32-34,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
熊去氧胆酸
婴儿
胆汁淤积症
治疗效果
Ursodeoxycholic Acid
Infant
Cholestasis
Therapeutic effect
